Washington University School of Medicine   |  
  
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Brad W. Warner, MD

Title
Pediatric Surgeon-in-Chief
St. Louis Children's Hospital

Appointment
Jessie L. Ternberg, MD PhD Distinguished Professor of Pediatric Surgery
Chief, Division of Pediatric Surgery
Washington University School of Medicine

Email
brad.warner@wustl.edu  

Phone
(314) 454-6022

Fax
(314) 454-2442

Credentials
MD: University of Missouri, Kansas City, MO, 1982.

Residency: Surgery, University of Cincinnati Hospital, Cincinnati, OH.

Fellowship: Pediatric Surgery, Children's Hospital Medical Center, Cincinnati, OH.

Certification: Surgery, 1990; Surgery, recertified 1998; Pediatric Surgery, recertified 2001; Surgical Critical Care, 1993.

Awards and Honors

  • E. Grey Dimond, MD, Take Wing Award, University of Missouri-Kansas City School of Medicine, 2008
  • Awarded "2007 Best Doctors"
  • Awarded "2006 Best Doctors"
  • Awarded "2005 Best Doctors"
  • James IVth Traveling Fellowship Award; (Australia/Great Britain/Ireland/Scotland), 2004
  • Elected Fellow of the American Surgical Association, 2005
  • Elected to Society of Clinical Surgery, 2005
  • Dean's List, 1976 to 1977 
  • University Scholar, 1976 to 1978 
  • Phi Kappa Phi, 1980 
  • Vice Chancellor for Student Affairs, Honor Recipient, 1982 
  • Best Surgical Resident Teaching Award, Department of Surgery, University of Cincinnati College of Medicine, 1984 to 1985, 1988 to 1989 
  • 3rd Place, Ohio Chapter American College of Surgeons Resident Essay Contest, 1987 
  • Honorable Mention, Ohio Chapter, American College of Surgeons Resident Essay Contest, 1987 
  • Max Zinninger Award, Department of Surgery, University of Cincinnati College of Medicine, 1987 
  • Alpha Omega Alpha, 1989 
  • Trauma Award, 2nd Place, Ohio Chapter, American College of Surgeons, Resident Essay Contest, 1989 
  • Surgical Biology Club (American College of Surgeons), 2001 
  • President, Society of University Surgeons, 2003 
  • Elected to Executive Committee; Surgical Section - American Academy of Pediatrics, 2003
  • America's Best Doctors, 2003

Research Grants and Contracts 

National Institutes of Health
2RO1 DK 53234-02 SB
1/98 to 4/08
Intestinal adaptation and epidermal growth factor
PI: BW Warner
 
National Institutes of Health
RO1 DK 59288-01 SB
2/02 to 6/12
Enterocyte apoptosis after intestinal resection
PI: BW Warner

Publications, Most Recent
(last four years)

Jarboe MD, Juno RJ, Stehr W, Bernal NP, Profitt S, Erwin CR, Warner BW: Epidermal growth factor receptor signaling regulates goblet cell production after small bowel resection. J Pediatr Surg, 40: 92-97, 2005.

Bernal NP, Stehr W, Zhang Y, Profitt S, Erwin CR, Warner BW: Evidence for active Wnt signaling during postresection intestinal adaptation. J Pediatr Surg, 40: 1025-1029, 2005.

Warner BW, Warner BB: Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis. Semin Pediatr Surg, 14: 175-180, 2005.

Stehr W, Mercer TI, Bernal NP, Erwin CR, Warner BW: Opposing roles for p21waf1/cip1 and p27kip1 in enterocyte differentiation, proliferation, and migration. Surgery, 138: 187-194, 2005.

Prasad V, Boivin GP, Miller ML, Liu LH, Erwin CR, Warner BW, Shull GE: Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic Reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility. Cancer Res, 65: 8655-8661, 2005.

Guo J, Sheng G, Warner BW: Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells. J Biol Chem, 43: 35992-35998, 2005.

Ignacio RC, Falcone RA Jr, Warner BW: Necrotizing fasciitis: a rare complication of neonatal necrotizing enterocolitis. J Pediatr Surg, 40: 1805-1807, 2005.

Stehr W, Bernal NP, Bernabe KQ, Erwin CR, Warner BW: Absent STAT1 expression perturbs adaptation and apoptosis after massive intestinal resection. J Pediatr Surg, 41: 713-718, 2006.

Bernal NP, Stehr W, Zhang Y, Profitt S, Erwin CR, Warner BW: Combined pharmacotherapy that increases proliferation and decreases apoptosis optimally enhances intestinal adaptation. J Pediatr Surg, 41: 719-724, 2006.

Stehr W, Bernal NP, Erwin CR, Bernabe KQ, Guo J, Warner BW: Roles for p21waf1/cip1 and p27kip1 during the adaptation response to massive intestinal resection. Am J Physiol Gastrointest Liver Physiol, 290: G933-G941, 2006.

Erwin CR, Jarboe MD, Sartor MA, Medvedovic M, Stringer K, Warner BW, Bates MD: Developmental characteristics of adapting mouse small intestine crypt cells. Gastroenterology, 130: 1324-1332, 2006.

Warner BW, Erwin CR: Critical roles for EGF receptor signaling during resection-induced intestinal adaptation. J Pediatr Gastroenterol Nutr, 43: S68-S73, 2006.

Sheng G, Bernabe KQ, Guo J, Warner BW: Epidermal growth factor receptor mediated proliferation of enterocytes requires p21waf1/cip1 expression. Gastroenterology, 131: 153-164, 2006.

Warner BB, Ryan AL, Seeger K, Leonard AC, Erwin C, Warner BW: Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis. J Pediatr, 358-363, 2007.

Taylor JA, Bernabe KQ, Guo J, Warner BW: Epidermal growth factor receptor–directed enterocyte proliferation does not induce Wnt pathway transcription. J Pediatr Surg, 42: 981-986, 2007.

Sheng G, Guo J, Warner BW: Epidermal growth factor receptor signaling modulates apoptosis via p38α MAPK-dependent activation of Bax in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol, 293: G599-G606, 2007.

Parvadia JK, Keswani SG, Vaikunth S, Maldonado AR, Marwan A, Stehr W, Erwin C, Uzvolgyi E, Warner BW, Yamano S, Taichman N, Crombleholme TM: Role of VEGF in small bowel adaptation after resection: The adaptive response is angiogenesis dependent. Am J Physiol Gastrointest Liver Physiol, 293: G591-G598, 2007.

Tantemsapya N, Meinzner-Derr J, Erwin CR, Warner BW: Body composition and metabolic changes associated with massive intestinal resection in mice. J Pediatr Surg, 43(1):14-19, 2008.

Nair R, Warner BB, Warner BW: Role of EGF and other growth factors in the prevention of necrotizing enterocolitis. Semin Perinatol, 32:107-113, 2008.

Book Chapters
Warner, B.W.: Congenital anomalies of the anorectum. Rudolph's Pediatrics 21st Edition (Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Siegel NJ, eds.) McGraw-Hill, New York, NY, 1457-1459, 2003.

Falcone, R.A. Jr.; Warner, B.W.: Short-Bowel Syndrome. Operative Pediatric Surgery (Ziegler MM, Azizkhan RG, Weber TR, eds). McGraw Hill, New York, NY, 699-712, 2003.

Warner, B.W.: Pediatric Surgery.  Sabiston's Textbook of Surgery 17th Edition (Townsend CM,  Beauchamp RD, Evers BM, Maddox KL eds.) Elsevier/Saunders, Philadelphia, PA, 2097-2134, 2004.

Falcone, R.A. Jr.; Warner, B.W.: Hirschsprung's disease. Surgical Decision Making 5th Edition (McIntyre RC, Stiegmann GV, Eiseman B, eds), 384-387, 2004.

Falcone, R.A. Jr.; Warner, B.W.: Short-Bowel Syndrome. Principles and Practice of Pediatric Surgery 2nd Edition. (Oldham KT, Colombani PM, Foglia RP, Skinner MA eds.) Lippincott Williams & Wilkins, Philadelphia, PA, 1207 – 1219, 2005.

Warner BW: Short Bowel Syndrome. In: Pediatric Surgery 6th Edition (Grosfeld JL, O’Neill JA, Fonkalsrud EW, Coran AG, eds.) Mosby Elsevier, Philadelphia PA, 1369-1382, 2006.

Warner BW: Congenital diaphragmatic hernia. In Mastery of Surgery 5th Edition. (Baker RJ, Fischer JE, eds). Lippincott Williams & Wilkins, Philadelphia PA, 618-625, 2007.

Warner BW: Esophageal atresia and tracheoesophageal fistula. In Pediatric Clinical Advisor: Instant Diagnosis and Treatment 2nd Edition (Garfunkel LC, Kaczorowski J, Christy C, eds). Mosby/ Elsevier, Philadelphia PA, 197-198, 2007.

Warner BW: Pediatric Surgery. In: Sabiston’s Textbook of Surgery  18th Edition (Townsend CM,  Beauchamp RD, Evers BM, Maddox KL eds.) Saunders Elsevier, Philadelphia PA, 2047-2089, 2007.

Editorials/Case Reports
Tiao, G.; Warner, B.W.: Transcription factors and cholangiocyte development. Gastroenterology 124: 263-264, 2003.

Erwin, C.R.; Jarboe, M.D.; Warner, B.W.: Zeroing in on the "holy grail." Gastroenterology 125:266-7, 2003.

Warner, B.W.: Enterocyte apoptosis and TPN-associated intestinal mucosal atrophy: A view of the chicken or the egg? Gastroenterology 125: 1273-1274, 2003.

Warner, B.W.; Falcone, R.A. Jr.: Images in clinical medicine: Pneumatosis intestinalis. J Pediatr 143: 543, 2003.

Erwin, C.R.; Warner, B.W.: Hirschprung lost his nerve. Gastroenterology 125: 1900-1902, 2003.

Stehr, W.; Warner, B.W.: High-fat nutrition for short gut syndrome: Another indication for the Atkin's diet? Gastroenterology 126: 920-921, 2004.

Ryckman, F.C.; Warner, B.W.: Barrett's esophagus after repair of esophageal atresia with tracheoesophageal fistula: yet another morbidity. Gastroenterology 126: 1913-1915, 2004.

Warner, B.W.: Diagnosing appendicitis in children: it comes down to the physical exam. Gastroenterology 127: 675-677, 2004.

Warner, B.W.: Society of University Surgeons Presidential Address: Professionalism and surgery: kindness and putting patients first. Surgery 136: 105-113, 2004.

Warner, B.W.: What's new in pediatric surgery. J Am Coll Surg 199:273-85, 2004.

Warner, B.W.: Tissue engineered small intestine: a viable clinical option? Ann Surg 240: 755-756, 2004.

Cobb, P.J.; Warner, B.W.: Challenges and a new vision for academic surgery. J Am Coll Surg 200: 605-606, 2005; Reply: J Am Coll Surg 201: 490, 2005.

Kim, E.S.; Warner, B.W.: Unexpected finding during inguinal hernia repair in a girl. Surgery 138: 954-955, 2005.

Professional Organization Memberships

Special Interests

  • Extracorporeal membrane oxygenation (ECMO)
  • Surgical nutrition
  • Ulcerative colitis
  • Short bowel syndrome
  • Necrotizing enterocolitis
  • Surgical oncology

Presentations, Most Recent

Stehr W, Mercer TI, Bernal NP, Erwin CR, Warner BW: “Opposing roles for p21waf1/cip1 and p27kip1 in enterocyte differentiation, proliferation, and migration.” Presented at the 66th Annual meeting of the Society of University Surgeons; February 9-12, 2005; Nashville TN.

Bernal NP, Stehr W, Bobo S, Erwin CR, Warner BW: “EGF rescues adaptation and survival in Bcl-w deficient mice after small bowel resection.” Presented at the 66th Annual meeting of the Society of University Surgeons; February 9-12, 2005; Nashville TN.

Warner BW: “Intestinal adaptation and surgical options following massive intestinal loss.” Presented at the 20th Annual International Meeting of the Egyptian Pediatric Surgical Association; December 15-17, 2004; Giza, Egypt.

Warner BW: “Role of epidermal growth factor in the pathogenesis of necrotizing enterocolitis.” Presented at the 3rd International Necrotizing Enterocolitis Symposium; Columbus Children’s Hospital; April 15-16, 2005; Columbus OH.

Ladd AP, Leonard A, Erwin CR, Warner BW, Warner BB: “Salivary EGF and necrotizing enterocolitis In VLBW infants.” Presented at The Society for Pediatric Research, May 14-17, 2005; Washington DC.

Stehr W, Bernal NP, Erwin CR, Warner BW: “Diminished expression of the cyclin dependent kinase inhibitor p27kip1 leads to an amplified adaptation response following intestinal resection.” Presented at Digestive Disease Week and the 106th Annual Meeting of the American Gastroenterological Association, May 14-19, 2005; Chicago IL.

Bernal NP, Stehr W, Zhang Y, Profitt S, Erwin CR, Warner BW: “Alterations in cell adhesion modulate the magnitude of resection-induced intestinal adaptation independent of enterocyte proliferation.” Presented at Digestive Disease Week and the 106th Annual Meeting of the American Gastroenterological Association, May 14-19, 2005; Chicago IL.

Warner BW: “Surgical options for management of ulcerative colitis.” Presented at the 27th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 17-22, 2005; Aspen CO.

Warner BW: “Necrotizing enterocolitis.” Presented at the 27th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 17-22, 2005; Aspen CO

Warner BW: “Surgical options for management of gastroesophageal reflux.” Presented at the 27th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 17-22, 2005; Aspen CO.

Warner BW: “Surgical options for management of short bowel syndrome.” Presented at the 27th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 17-22, 2002005; Aspen CO.

Warner BW: “Resection-induced intestinal adaptation.” Presented at the 27th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 17-22, 2005; Aspen CO.

Warner BW: “Update on Children’s Hospital.” Presented at the 79th Annual Meeting of the Halsted Society, September 9, 2005; Cincinnati OH.

Stehr W, Bernal NP, Bernabe KQ, Erwin CR, Warner BW: “STAT1 is an inhibitor of adaptation after massive small bowel resection.” Presented at the American Academy of Pediatrics - Surgical Section, October 8-11, 2005; Washington DC.

Bernabe KQ, Bernal NP, Stehr W, Erwin CR, Warner BW: “Resection-induced intestinal adaptation and the role for enteric smooth muscle: cause or effect?” Presented at the American Academy of Pediatrics - Surgical Section, October 8-11, 2005; Washington DC.

Bernal NP, Syehr W, Zhang Y, Profitt S, Erwin CR, Warner BW: “Combined pharmacotherapy that increases proliferation and decreases apoptosis optimally enhances intestinal adaptation.” Presented at the American Academy of Pediatrics - Surgical Section, October 8-11, 2005; Washington DC.

Parvadia J, Vaikunth S, Marwan A, Harkness U, Maldonado A, Alaee D, Kalinowska B, Stehr W, Uzvolgyi E, Erwin C, Warner B, Crombleholme T: “Role of vascular endothelial growth factor (VEGF) in small bowel adaptation after resection: EGF is VEGF dependent for the adaptive response.” Presented at the American Academy of Pediatrics - Surgical Section, October 8-11, 2005; Washington DC.

Sheng GS, Warner BW: “EGF receptor signaling induces proliferation of intestinal epithelial cells via MAPK-directed increase in p21 expression.” Presented at the 66th Annual meeting of the Society of University Surgeons, 1st Academic Surgical Congress, February 7-11, 2006; San Diego CA .

Hildebrandt MA, Yong Q, Thrasher SM, McVay LM, Stehr W, Warner BW, Appleton JA, Ahima RS, Wu GD: "RELMβ is an intestinal epithelial-derived hormone responsible for host metabolic adaptation to chronic parasitic nematode infections." Presented at Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association, May 14-19, 2006; Los Angeles CA.

Warner BW: “Intestinal rehabilitation: potential role of growth factors.” Presented at the Fourth International Intestinal Failure and Rehabilitation Symposium, University of Pittsburgh Medical Center, June 1-3, 2006; Pittsburgh PA.

Warner BW: “EGF receptor signaling as mechanism for regulation of resection-induced adaptation.” Presented at the Digestive Diseases Interagency Coordinating Committee Joint Workshop for New Therapies and Preventive Approaches for Necrotizing Enterocolitis, National Institutes of Health, July 10-11, 2006, Bethesda MD.

Sheng GS, Warner BW: “Intestinal epithelial cell apoptosis requires Bax activation via p38 MAP kinase.” Presented at the 92nd Annual Clinical Congress of The American College of Surgeons Surgical Forum, October 8-12, 2006; Chicago IL.

Taylor JA, Bernabe KQ, Guo J, Warner BW: “Nuclear β-catenin is not involved in the enterocyte proliferation response to epidermal growth factor receptor stimulation.” Presented at the American Academy of Pediatrics - Surgical Section, October 6-8, 2006; Atlanta GA.

Bernabe KQ, Sheng G, Guo J, Erwin CR, Warner BW: “Intestinal epithelial cell proliferation is influenced by smooth muscle cell production of amphiregulin.” Presented at the American Academy of Pediatrics - Surgical Section, October 6-8, 2006; Atlanta GA.

Sheng G, Warner BW: “Epidermal growth factor receptor inhibition mediated increase in intestinal epithelial cell apoptosis requires p38 MAP kinase dependent Bax activation.” Presented at the American Academy of Pediatrics - Surgical Section, October 6-8, 2006; Atlanta GA.

Taylor JA, Guo J, Warner BW: “Evidence for retinoblastoma protein involvement in resection-induced enterocyte proliferation.” Presented at the 2nd Academic Surgical Congress, February 6-9, 2007; Phoenix AZ.

Warner BW: “Resection-induced intestinal adaptation – new paradigms of regulation.” Presented at the 19th Annual Moses Gunn Research Conference, University of Michigan, April 3, 2007, Ann Arbor MI.

Warner BW: “Physiologic basis of intestinal adaptation.” Presented at Digestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association, May 21, 2007; Washington DC.

Tantemsapya N, Meinzen-Derr J, Warner BW: “Body composition and metabolic changes associated with massive intestinal resection.” Presented at the 38th Annual Meeting of the American Pediatric Surgical Association, May 24-27, 2007; Orlando FL.

Warner BW: “Surgical options for management of ulcerative colitis.” Presented at the 29th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 17-22, 2005; Aspen CO.

Warner BW: “Necrotizing enterocolitis.” Presented at the 29th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 22-27, 2007; Aspen CO

Warner BW: “Gastroesophageal reflux.” Presented at the 29th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 22-27, 2007; Aspen CO.

Warner BW: “Surgical options for management of short bowel syndrome.” Presented at the 29th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 22-27, 2007; Aspen CO.

Warner BW: “Resection-induced intestinal adaptation.” Presented at the 29th Annual Aspen Conference on Pediatric Gastrointestinal Disease – Pediatric Gastrointestinal Disease and Intestinal Transplantation, July 22-27, 2007; Aspen CO.

Warner BW: “EGF receptor signaling and enterocyte apoptosis: tools for the future?” Presented at International Surgical Week; 42nd World Congress of the International Surgical Society, August 30, 2007; Montreal, Canada.

Martin CA, Bernabe KQ, Taylor JA, Nair R, Sheng G, Warner BW: “Contractility and phenotype changes in smooth muscle after bowel resection.”  Presented at the American Academy of Pediatrics - Surgical Section, October 26-28, 2007; San Francisco CA.

Taylor JA, Martin CA, Guo J, Erwin CR, Warner BW: Lessons learned: optimization of the murine small bowel resection model.” Presented at the American Academy of Pediatrics - Surgical Section, October 26-28, 2007; San Francisco CA.


Invited Visiting Professor 

  • Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN, January 29-30, 2003.
  • Division of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, March 26-27, 2003.
  • Sacramento Surgical Society, Department of Surgery, University of California – Davis, Sacramento, CA, July 10, 2003.
  • George H.A. Clowes Visiting Professor in Surgical Research, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, January 13-14, 2004.
  • Department of Surgery, Rochester University School of Medicine and Dentistry, Rochester, NY, March 10-11, 2004.
  • Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, August 24 - 25, 2004.
  • Eric R. Fonkalsrud Distinguished Lectureship, Division of Pediatric Surgery; University of California, Los Angeles; David Geffen School of Medicine; Los Angeles, CA; October 25-27, 2004.
  • Department of Surgery, University of Texas Medical Branch – Galveston, TX; November 9-10, 2004.
  • Thomas V. Santulli, M.D. Lectureship, Department of Pediatric Surgery - Morgan Stanley Children's Hospital of New York; Columbia/Presbyterian University Medical Center; New York, NY; April 27-29, 2005.
  • David Tapper M.D. Memorial Lectureship, Department of Pediatric Surgery – Children’s Hospital of Seattle, University of Washington School of Medicine; Seattle WA; April 26-28, 2006.
  • Department of Surgery, University of Michigan Medical School – Keynote Speaker, 19th Annual Moses Gunn Research Conference; Ann Arbor MI, April 3, 2007.
  • Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX  January 9-10, 2008.

Related Areas:


Washington University physicians are the medical staff of Barnes-Jewish Hospital and St. Louis Children's Hospital


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