Christopher R. Erwin, PhD
Appointment
Associate Professor of Surgery
Division of Pediatric Surgery
Washington University School of Medicine
Email
erwinc@WUSTL.EDU
Phone
(314) 454-6022
Fax
(314) 454-2442
Credentials
PhD: University of Iowa, Iowa City, IA, 1983.
Fellowship: Post Doctoral Fellow, Hormone Research Institute, University of California, San Francisco, CA.
Publications, Most recent
Knott AW, Erwin CR, Profitt SA, Juno RJ, Warner BW: Localization of Postresection EGF Receptor expression using Laser Capture Microdissection. Journal of Pediatric Surgery, 38(4):440-445, 2003.
Juno RJ, Knott AW, Erwin CR, Warner BW: Serum Factor(s) After Small Bowel Resection Induces Intestinal Epithelial Cell Proliferation: Effects of Timing, Site, and Extent of Resection. Journal of Pediatric Surgery, 38(6)868-874, 2003
Knott AW, Juno RJ, Jarboe MD, Zhang Y, Profitt SA, Thoerner JC, Erwin CR, Warner BW: EGF Receptor Signaling Affects Bcl-2 Family Gene Expression After Massive Small Bowel Resection. Journal of Pediatric Surgery, 38(6)875-880, 2003
Erwin CR, Jarboe MD, Warner BW: Zeroing in on the "Holy Grail." Gastroenterology, 125(1):266-267, 2003.
Andrew AW, O'Brien DP, Juno RJ, Zhang Y, Erwin CR, Warner BW: Enterocyte Apoptosis after massive small bowel resection in mice is activated independent of the extrinsic death receptor pathways. American Journal of Physiology (Gastrointestinal and Liver Physiology), 285: G404-G413, 2003.
Juno RJ, Knott AW, Jarboe MD, Profitt S, Erwin CR, Warner BW: Characterization of small bowel resection and intestinal adaptation in germ free rats. Surgery, 134: 582-590, 2003.
Erwin CR and Warner BW: Hirschsprung Lost His Nerve. Gastroenterology. 125: 1900-1902, 2003.
Juno RJ, Knott AW, Profitt S, Jarboe MD, Zhang Y, Erwin CR, Warner BW: Preventing enterocyte apoptosis after massive small bowel resection does not enhance adaptation of the intestinal mucosa. Journal of Pediatric Surgery, 39(6): 907-911, 2004.
Jarboe MD, Juno RJ, Bernal NP, Knott AW, Zhang Y, Erwin CR, Warner BW: Bax deficiency rescues resection-induced enterocyte apoptosis in mice with perturbed EGF receptor function. Surgery, 136(2): 121-2126, 2004.
Knott AW, Juno RJ, Jarboe MD, Profitt SA, Erwin CR, Smith EP, Fagin JA, Warner BW: Smooth muscle overexpression of IGF-1 induces a novel adaptive response to small bowel resection. American Journal of Physiology (Gastrointestinal and Liver Physiology), 287(3):G562-G570, 2004.
Jarboe MD, Juno RJ, Stehr W, Bernal NP, Profitt S, Erwin CR, Warner BW: Epidermal growth factor receptor signaling regulates goblet cell production after small bowel resection. Journal of Pediatric Surgery, 40: 92-97, 2005
Bernal NP, Stehr W, Zhang Y, Profitt S, Erwin CR, Warner BW: Evidence for active Wnt signaling during postresection intestinal adaptation. Journal of Pediatric Surgery, 40(6):1025-9, 2005.
Prasad V, Boivin GP, Liu LH, Erwin CR, Warner BW, Shull GE: Haploinsufficiency of Atp2a2, encoding the sarco/endoplasmic reticulum Ca2+-ATPase isoforms 2, predisposes mice to squamous tumors, defining a novel mode of cancer susceptibility. Cancer Research, 65(19):8655-61, 2005.
Stehr W., Mercer TI, Bernal NP, Erwin CR, Warner BW: Opposing roles for p21waf1/cip1 and p27kip1 in enterocyte differentiation, proliferation, and migration. Surgery, 138(2):187-94, 2005.
Research
Study adaptation after small bowel resection with special interest in the effects of EGF using a molecular biology approach.
Special Interests
Director, Laser Capture Microdissection Core
Recent Presentations
Juno RJ, Knott AW, Jarboe MD, Profitt S, Erwin CR, Warner BW: Characterization of small bowel resection and intestinal adaptation in germ free rats. Presented at 60th Annual Meeting of the Central Surgical Association, March 20-22, 2003; Toronto, Ontario.
Juno RJ, Knott AW, Jarboe MD, Erwin CR, Warner BW: p21 is elevated and intestinal adaptation is preserved in p27-null mice following small bowel resection. Presented at the American Gastroenterological Association, May 17-22, 2003; Orlando FL.
Knott AW, Juno RJ, Erwin CR, Smith EP, Fagin JA, Warner BW: Smooth muscle overexpression of insulin-like growth factor-1 results in a novel adaptive response to massive small bowel resection. Presented at the American Gastroenterological Association, May 17-22, 2003; Orlando FL.
Knott AW, Juno RJ, Jarboe MD, Profitt S, Zhang Y, Erwin CR, Warner BW: Bcl-w deficiency perturbs enterocyte apoptosis and proliferation. Presented at the 37h Annual Meeting of the Association for Academic Surgery, November 13 - 15, 2003; Sacramento CA.
Jarboe MD, Juno RJ, Bernal NP, Knott AW, Erwin CR, Warner BW: Bax deficiency rescues resection-induced enterocyte apoptosis in mice with perturbed EGF receptor function. Presented at the 65th Annual Meeting of the Society of University Surgeons, February 11-14, 2004; St. Louis MO.
Jarboe MD, Stehr W, Bernal NP, Profitt SA, Zhang Y, Erwin CR, Warner BW: STAT-1 signaling is a critical downstream mediator of enterocyte proliferation and intestinal adaptation. Presented at Digestive Disease Week and the 105th Annual Meeting of the American Gastroenterological Association, May 15-20, 2004; New Orleans LA.
Erwin CR, Jarboe M, Bernal N, Stehr W, Medvedovic M, Sartor M, Warner B: Gene expression profiles of post-resection adapting crypt enterocytes isolated by laser capture microdissection (LCM). Presented at Digestive Disease Week and the 105th Annual Meeting of the American Gastroenterological Association, May 15-20, 2004; New Orleans LA.
Jarboe MD, Juno RJ, Stehr W, Bernal NP, Profitt S, Erwin CR, Warner BW: Epidermal growth factor receptor signaling regulates increases in goblet cell mass after small bowel resection. Presented at the 35th Annual Meeting of the American Pediatric Surgical Association, May 27-30, 2004; Ponte Vedra Beach FL.
Bernal NP, Stehr W, Zhang Y, Profitt S, Erwin CR, Warner BW: Evidence for active Wnt signaling during postresection intestinal adaptation. Presented at the American Academy of Pediatrics - Surgical Section, October 9-13, 2004; San Francisco CA.
Bernal NP, Erwin CR, Stehr W, Jarboe M, Proffit S, Zhang Y, Warner BW: Combined stimulation of enterocyte proliferation and inhibition of apoptosis maximally enhances intestinal adaptation. Presented at the 38th Annual Meeting of the Association for Academic Surgery, November 11-13, 2004; Houston TX.
Stehr W, Mercer TI, Bernal NP, Erwin CR, Warner BW: Opposing roles for p21waf1/cip1 and p27kip1 in enterocyte differentiation, proliferation, and migration. Presented at the 66th Annual Meeting of the Society of University Surgeons, February 9-12, 2005; Nashville TN.
Bernal NP, Stehr W, Bobo S, Erwin CR, Warner BW: EGF rescues adaptation and survival in Bcl-w deficient mice after small bowel resection. Presented at the 66th Annual Meeting of the Society of University Surgeons, February 9-12, 2005; Nashville TN.
Ladd AP, Leonard A, Erwin CR, Warner BW, Warner BB: Salivary EGF and necrotizing enterocolitis In VLBW infants. Presented at The Society for Pediatric Research, May 14-17, 2005; Washington DC.
Stehr W, Bernal NP, Erwin CR, Warner BW: Diminished expression of the cyclin dependent kinase inhibitor p27kip1 leads to an amplified adaptation response following intestinal resection. Presented at Digestive Disease Week and the 106th Annual Meeting of the American Gastroenterological Association, May 14-19, 2005; Chicago IL.
Bernal NP, Stehr W, Zhang Y, Profitt S, Erwin CR, Warner BW: Alterations in cell adhesion modulate the magnitude of resection-induced intestinal adaptation independent of enterocyte proliferation. Presented at Digestive Disease Week and the 106th Annual Meeting of the American Gastroenterological Association, May 14-19, 2005; Chicago IL.
Related Areas:
Washington University Division of Pediatric Surgery