Peter S. Goedegebuure Ph.D.

Washington University School of Medicine \|	Department of Surgery Find Find Facilities Living in St. Louis Maps & Directions Travel & Lodging Physician Resources Research Research Faculty Research Research Faculty Directory Research Education BioMed 21 Training Training Home Patient Care Patient Care Find a Surgeon Clinical Directory Find Information Surgical Areas Cardiothoracic General Surgery --- Acute & Critical Care --- Colon - Rectal --- Enocrine & Oncologic --- HPB & GI --- Minimally Invasive --- Transplant --- Vascular Pediatric Plastic & Reconstructive --- Cosmetic --- West County Plastic Urologic

Peter S. Goedegebuure Ph.D. Endocrine and Oncologic Surgery
Research Interest Immune response to breast and pancreas cancer
Mechanisms of immune system recognition of cancer
Identification of tumor antigens on breast and pancreas cancer
Development of vaccines for treatment
Funding NIH, shared with Timothy J. Eberlein, M.D.
Selected or Recent Publications Liyanage UK, Goedegebuure PS, Moore TT, Viehl CT, Moo-Young TA, Larson JW, Frey DM, Ehlers JP, Eberlein TJ, Linehan DC. Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma. J Immunother. 2006. (in press) Linehan DC, Goedegebuure PS. CD25+CD4+ Regulatory T-Cells in Cancer. Immunol Res. 2005;32(1-3):155-168. Viehl CT, Tanaka Y, Chen T, Frey DM, Tran A, Fleming TP, Eberlein TJ, Goedegebuure PS. Tat mammaglobin fusion protein transduced dendritic cells stimulate mammaglobin-specific CD4 and CD8 T cells. Breast Cancer Res Treat. 2005;91(3):271-278. Viehl CT, Becker-Hapak M, Lewis JS, Tanaka Y, Liyanage UK, Linehan DC, Eberlein TJ, Goedegebuure PS. A Tat Fusion Protein–Based Tumor Vaccine for Breast Cancer. Ann Surg Oncol. 2005;12(7):517-525. Epub 2005 May 10. Goedegebuure PS, Watson MA, Viehl CT, Fleming TP. Mammaglobin-based strategies for treatment of breast cancer. Curr Cancer Drug Targets. 2004 Sep;4(6):531-542. Joo H-G, Fleming TP, Tanaka Y, Dunn TJ, Linehan DC, Goedegebuure PS, Eberlein TJ. Human dendritic cells induce tumor-specific apoptosis by soluble factors. International Journal of Cancer. 2002;102(1):20-28. Von Bernstorff W, Glickman JN, Odze RD, Farraye FA, Joo H-G, Goedegebuure PS, Eberlein TJ. Fas (CD95/APO-1) and Fas ligand expression in normal and pancreatic tumors: Implications for immune privilege and immune escape. Cancer. 2002;94:2552-2560. Tanaka Y, Amos K, Fleming TP, Eberlein TJ, Goedegebuure PS. Mammaglobin-A is a tumor-associated antigen in human breast carcinoma. Surgery. 2002. (in press) Tanaka Y, Amos KD, Joo H-G, Eberlein TJ, Goedegebuure PS. Modification of the Her2/neu-derived tumor antigen GP2 improves induction of GP2-reactive cytotoxic T lymphocytes. International Journal of Cancer. 2001;94(4):540-544. Peoples GE, Goedegebuure PS, Smith R, Linehan DC, Yoshino I, Eberlein TJ. Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide. Proceedings of the National Academy of Sciences. 1995;92:432-436.

Washington University physicians are the medical staff of Barnes-Jewish Hospital and St. Louis Children's Hospital