Paul Goodfellow Ph.D.

Washington University School of Medicine \|	Department of Surgery Find Find Facilities Living in St. Louis Maps & Directions Travel & Lodging Physician Resources Research Research Faculty Research Research Faculty Directory Research Education BioMed 21 Training Training Home Patient Care Patient Care Find a Surgeon Clinical Directory Find Information Surgical Areas Cardiothoracic General Surgery --- Acute & Critical Care --- Colon - Rectal --- Enocrine & Oncologic --- HPB & GI --- Minimally Invasive --- Transplant --- Vascular Pediatric Plastic & Reconstructive --- Cosmetic --- West County Plastic Urologic

	Paul Goodfellow Ph.D. Endocrine and Oncologic Surgery
Research Interest The research in my laboratory is focused on the discovery of genetic factors that contribute to the development of common human malignancies. We are particularly interested in elucidating the inherited factors that predispose to cancer development and how they interact with acquired genetic damage. We are presently working to:
Characterize a putative tumor suppressor gene important in endometrial and renal cancers.
Elucidate the role that defective DNA mismatch repair plays in endometrial cancers.
Funding National Institutes of Health
Selected or Recent Publications Noonan FC, Mutch DG, Ann Mallon M, Goodfellow PJ. Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis, and a search for mutations in endometrial cancers. Genomics. 2001;76(1-3):37-44. Whelan AJ, Bartsch D, Goodfellow PJ. A familial syndrome of pancreatic cancer and melanoma associated with mutation in the CDKN2 tumor suppressor gene. New England Journal of Medicine. 1995;333:975-977. Ogunbiyi OA, Goodfellow PJ, Gagliardi G, Swanson PE, Birnbaum EH, Fleshman JW, Kodner IJ, Moley J. Prognostic value of chromosome 1p allelic loss in colon cancer. Gastroenterology. 1997;113:761-766. Ogunbiyi OA, Goodfellow PJ, Herfarth K, Gagliardi G, Swanson PE, Birnbaum EH, Read TE, Fleshman JW, Kodner IJ, Moley J. Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. Journal of Clinical Oncology. 1998;16:427-433. Simpkins SB, Bocker T, Swisher EM, Mutch DG, Gersell DJ, Kovatich AJ, Palazzo JP, Fishel R, Goodfellow PJ. MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers. Human Molecular Genetics. 1999;8:661-666.
Active Funding American Cancer Society: Cloning a tumor suppressor gene important in endometrial tumorigenesis
National Cancer Institute: Defective DNA mismatch repair in endometrial cancers

Washington University physicians are the medical staff of Barnes-Jewish Hospital and St. Louis Children's Hospital