Yian Wang M.D., Ph.D.

Washington University School of Medicine \|	Department of Surgery Find Find Facilities Living in St. Louis Maps & Directions Travel & Lodging Physician Resources Research Research Faculty Research Research Faculty Directory Research Education BioMed 21 Training Training Home Patient Care Patient Care Find a Surgeon Clinical Directory Find Information Surgical Areas Cardiothoracic General Surgery --- Acute & Critical Care --- Colon - Rectal --- Enocrine & Oncologic --- HPB & GI --- Minimally Invasive --- Transplant --- Vascular Pediatric Plastic & Reconstructive --- Cosmetic --- West County Plastic Urologic

	Yian Wang M.D., Ph.D. Cancer Prevention and Control Associate Professor of Surgery Division of General Surgery
Medical Education BS/MD, Beijing Medical College, Beijing, China, 1982 PhD, Medical College of Ohio, Toledo, OH, 1990
Research Interest 1) Cancer chemoprevention and 2) Genetic susceptibility to tumor development.
Selected or Recent Publications Wang M, Lemon WJ, Liu G, Wang Y, Iraqi FA, Malkinson AM, You M. Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Cancer Res. 2003;63:3317-3324. De Flora S, Balansky RM, D'Agostini F, Izzotti A, Camoirano A, Bennicelli C, Zhang Z, Wang Y, Lubet RA, You M. Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke. Cancer Res. 2003;63:793-800. Wang Y, Zhang Z, Kastens E, Lubet RA, You M. Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Cancer Res. 2003;63:4389-4395. Lemon WJ, Swinton CH, Wang M, Berbari N, Wang Y, You M. Single nucleotide polymorphism (SNP) analysis of mouse pulmonary adenoma susceptibility loci 1-4 for identification of candidate genes. J Med Genet. 2003;40: e36. Yao R, Wang Y, Lubet RA, You M. Differential gene expression in chemically induced mouse lung adenomas. Neoplasia. 2003;5:41-52. Li J, Zhang Z, Dai Z, Plass C, Morrison C, Wang Y, Wiest JS, Anderson MW, You M. LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. Oncogene. 2003;22:1243-1246. Zhang Z, Wang Y, Lantry LE, Kastens E, Liu G, Hamilton AD, Sebti SM, Lubet RA, You M. Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. Oncogene. 2003;22:6257-6265. Zhang Z, Li J, Lantry LE, Wang Y, Wiseman RW, Lubet RA, You M. p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas. Cancer Res. 2002;62:3024-3029. Zhang Z, Wang Y, Herzog CR, Liu G, Lee HW, DePinho RA, You M. A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. Oncogene. 2002;21:5960-5966.
Personal Website Chemoprevention Laboratory

Washington University physicians are the medical staff of Barnes-Jewish Hospital and St. Louis Children's Hospital