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 | Ming You M.D., Ph.D.
Cancer Prevention and Control
Professor of Surgery
Division of General Surgery | Medical Education
BS/MD, Beijing Medical College, Beijing, China, 1982
PhD, Pathology, Medical College of Ohio, Toledo, Ohio, 1989 | Research Interest
Chemoprevention and genetics of lung cancer, including three major projects: 1) lung cancer chemoprevention studies in rodent models with the goals of identifying new effective agents and elucidation of their mechanisms of action; 2) identification of human and mouse lung cancer susceptibility gene(s); 3) functional analysis of lung cancer genes using transgenic mice. | Selected or Recent Publications
Wang M, Wang Y, You M. Identification of genetic polymorphisms through comparative dna sequence analysis on the K-ras gene: implications for lung tumor susceptibility. Exp Lung Res. 2005;31:165-177.
Yao R, Wang Y, D'Agostini F, Izzotti A, Lubet RA, You M, DeFlora S. K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke. Exp Lung Res. 2005;31: 271-281.
Wang M, Wang Y, You M, Devereux TR. Analysis of the Par2 modifier of pulmonary adenoma formation in mice. Exp Lung Res. 2005;31:193-204.
Wang M, Futamura M, Wang Y, You M. Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. Oncogene. 2005;24:1958-1963.
Wang Y, Zhang Z, Lubet R, You M. Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf. Oncogene. 2005;24:3042-3049.
Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, deAndrade M, Wiest JS, Fain P, Schwartz AG, You M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson MW. A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet. 2004;75:460-474.
Garbow JR, Zhang Z, You M. Detection of primary lung tumors in rodents by magnetic resonance imaging. Cancer Res. 2004;64:2740-2742.
Izzotti A, Cartiglia C, Longobardi M, Bagnasco M, Merello A, You M, Lubet RA, DeFlora S. Gene expression in the lung of p53 mutant mice exposed to cigarette smoke. Cancer Res. 2004;64:8566-8572.
Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Res. 2004;64:1924-1931.
Wang Y, Zhang Z, Yan Y, Lemon WJ, LaRegina M, Morrison C, Lubet R, You M. A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility. Cancer Res. 2004;64:1647-1654.
Meyer AM, Dwyer-Nield LD, Hurteau GJ, Keith RL, O'Leary E, You M, Bonventre JV, Nemenoff RA, Malkinson AM. Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Carcinogenesis. 2004;25:1517-1524.
Lubet RA, Zhang Z, Wang Y, You M. Chemoprevention of lung cancer in transgenic mice. Chest. 2004;125:144S-147S.
Yan Y, Wang M, Lemon WJ, You M. Single nucleotide polymorphism (SNP) analysis of mouse quantitative trait loci for identification of candidate genes. J Med Genet. 2004;41:e111.
Bonner AE, Wang Y, You M. Gene expression profiling of mouse teratocarcinomas uncovers epigenetic changes associated with the transformation of mouse embryonic stem cells. Neoplasia. 2004;6:490-502.
Yao R, Lemon WJ, Wang Y, Grubbs CJ, Lubet RA, You M. Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine. Neoplasia. 2004;6:569-577.
Pub Med for Ming You, M.D., Ph.D. | Personal Website
Chemoprevention Laboratory |
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