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 | Julie A. Margenthaler M.D.
Endocrine and Oncologic Surgery
Assistant Professor of Surgery | Board Certification
Board certified -- American Board of Surgery | Appointments
Member, Barnes-Jewish Hospital Cancer Committee
WUSM Physician Liaison, American College of Surgeons’ Commission on Cancer | Specialty Areas
Breast cancer | Areas of Clinical Interest
Breast cancer in young women (<40 years old)
Patients with high risk factors for breast cancer
Familial breast cancer
Breast reconstruction liaison
Sentinel lymph node biopsy
| Medical School
Southern Illinois University School of Medicine, 1997 | Postdoctoral Education
General Surgery Residency (PGY-1, 2): Saint Louis University Hospitals, 1997-99
Postdoctoral Research Fellowship: Washington University School of Medicine, 1999-2002
General Surgery Residency (PGY-3-5): Washington University School of Medicine, 2002-2005
Breast Disease Fellowship: Washington University, 2005-2006 | Patients Seen At
Center for Advanced Medicine
Joanne Knight Breast Health Center
4921 Parkview Place, Suite F, Floor 5
St. Louis, MO 63110
(314) 362-2280 | Patient Appointments
(314) 362-2280 | Hospital Affiliations
Barnes-Jewish Hospital | Research Interest
Staging of the axilla in breast cancer patients
Breast cancer vaccine development
Breast cancer genetics | Funding
Susan G. Komen Breast Cancer Foundation STEP Grant, 2007-2008. Project: Reducing delays in cancer diagnosis in the St. Louis public safety net system.
James Ewing Foundation of the Society of Surgical Oncology, 2006-2007. Project: Minimally invasive staging of the axilla in breast cancer.
Longer Life Foundation, 2006-007. Project: Minimally invasive staging of the axilla in breast cancer using RT-PCR.
Clinical Trials
(Principal Investigator only)
#05-0956. “Outcomes of Patients with Primary Breast Sarcoma.” (closed)
#05-0957, “Effect of Surgical Resection of Primary Breast Cancers in Patients with Stage IV Disease at the Time of Diagnosis.” (closed)
#06-0351, “Treatment and Outcome of Patients with Intracystic Papillary Carcinoma of the Breast.” (closed)
#06-0425, “Recurrence of Breast Cancer after Skin Sparing Mastectomy.” (closed)
#06-0530, “Minimally Invasive Staging of the Axilla in Breast Cancer: A Pilot Study to Assess the Feasibility and Sensitivity of Real-Time PCR, Axillary Ultrasound, and Fine Needle Aspiration Biopsy.”
#06-0949, “Characteristics and Outcomes of Patients with Metastatic Tumors to the Breast.” (closed)
#07-0302, “Risk Factors for Benign Breast Abscesses.” (closed)
#07-0622, “Reducing Delays in Cancer Diagnosis in the St. Louis Public Safety Net System.”
#07-0623 “Evaluating the Sensitivity and Specificity of Axillary Ultrasound and Fine Needle Aspiration Biopsy in Staging the Axilla of Patients with Early Stage Breast Cancer.”
#07-0699, “Is Sentinel Lymph Node Staging Accurate in Patients with Multicentric Breast Cancer?”
#07-0700, “Predictors of Developing Contralateral Breast Cancer in Young Women (<40 Years Old).”
#07-0973, “Examining Factors that Contribute to the Diagnosis of Late-Stage Breast Cancer (Stage III and IV) at a Publicly Funded Community Health Center.” | Awards/Honors
James Ewing Foundation grant, Society of Surgical Oncology (2006-2007)
Eugene M. Bricker Teaching Award (2005)
SUS/Ethicon Research Award (2000-2002)
NRSA/NIH Fellowship (2000-2002)
ALF Postdoctoral Fellowship Award (2000-2001)
Resident Teaching Award, 2004 | Selected or Recent Publications
Fayanju OM, Ritter J, Gillanders WE, Eberlein TJ, Dietz JR, Aft R, Margenthaler JA. Therapeutic management of intracystic papillary carcinoma of the breast: the roles of radiation and endocrine therapy. American Journal of Surgery. 2007;194(4):497-500.
Vaughan A, Dietz JR, Aft R, Gillanders WE, Eberlein TJ, Freer P, Margenthaler JA. Scientific Presentation Award. Patterns of local breast cancer recurrence after skin-sparing mastectomy and immediate breast reconstruction. American Journal of Surgery. 2007;194(4):438-43.
Fields RC, Jeffe DB, Trinkaus K, Zhang Q, Arthur C, Aft R, Dietz JR, Eberlein TJ, Gillanders WE, Margenthaler JA. Surgical resection of the primary tumor is associated with increased long-term survival in patients with stage IV breast cancer after controlling for site of metastasis. Annals of Surgical Oncology. 2007;14(12):3345-3351. Epub 2007 Aug 9.
Vaughan A, Dietz JR, Moley JF, Debenedetti MK, Aft RL, Gillanders WE, Eberlein TJ, Ritter J, Margenthaler JA. Metastatic disease to the breast: the Washington University experience. World Journal of Surgical Oncology. 2007;5:74.
Gnerlich J, Jeffe DB, Deshpande AD, Beers C, Zander C, Margenthaler JA. Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988-2003 SEER data. Annals of Surgical Oncology. 2007;14(8):2187-2194. Epub 2007 May 24
Margenthaler JA, Duke D, Monsees BS, Barton PT, Clark C, Dietz JR. Correlation between core biopsy and excisional biopsy in breast high-risk lesions. American Journal of Surgery. 2006;192(4):534-537.
Margenthaler JA, Longo WE, Virgo KS, Johnson FE, Grossmann EM, Schifftner TL, Henderson WG, Khuri SF. Risk factors for adverse outcomes following surgery for small bowel obstruction. Annals of Surgery. 2006;243(4):456-464.
Margenthaler JA, Flye MW. Regional oral tolerance in transgenic 2C mice. Surgery. 2005;138(2):141-149.
Margenthaler JA, Flye MW. The immunologic function of 1B2+ double negative (CD4-CD8-) T cells in the 2C transgenic mouse. Journal of Surgical Research. 2005;126(2):160-166.
Margenthaler JA, Dietz DW, Mutch MG, Birnbaum EH, Kodner IJ, Fleshman JW. Outcomes, risk of other malignancies, and need for formal mapping procedures in patients with perianal Bowen's disease. Diseases of the Colon and Rectum. 2004;47:1655-1661.
Margenthaler JA, Kataoka M, Flye WM. Oral and portal venous tolerance in the interferon-gamma knockout (GKO) mouse. Journal of Surgical Research. 2004;119(2):107-112.
Margenthaler JA, Kataoka M, Flye MW. Peripheral tolerance in transgenic mice expressing class I MHC L(d) only on cardiac cells. Transplant Immunology. 2004;12(2):133-141.
Margenthaler JA, Weber TR, Keller MS. Predictors of surgical outcome for complicated pneumonia in children: impact of bacterial virulence. World Journal of Surgery. 2004;28(1):87-91.
Kataoka M, Margenthaler JA, Ku G, Eilers M, Flye MW. "Infectious tolerance" develops after the spontaneous acceptance of Lewis-to-Dark Agouti rat liver transplants. Surgery. 2003;134(2):227-234.
Margenthaler J, Yu S. Otomo N, Lehmann M, Flye MW. Donor specific renal, but not cardiac, allograft tolerance promotes engraftment of the normally rejected rat skin graft. Transplant International. 2003;16:713-720.
Pub Med for Julie A. Margenthaler, M.D. | Selected or Recent Chapters
Margenthaler J and Klingensmith ME. Stomach. In: Klingensmith ME (ed.). Washington University Manual of Surgery. 4th Edition. Philadelphia: Lippincott Williams & Wilkins; 2005.
Margenthaler J, Schuerer D, Whinney R. Acute cholecystitis. In: Clinical Evidence. 11th edition. BMJ Publishing Group; 2004:524-532.
Margenthaler J, Hermann VM, Hickey MS. Surgical Metabolism and Nutrition. In: Way LW, Doherty GM (eds.). Current Surgical Diagnosis & Treatment. 11th edition. Chapter 11, pp. 156-190.
Margenthaler J, Hermann VM. Nutrition. In: Doherty GM (ed.). Washington University Manual of Surgery. 3rd Edition. Philadelphia: Lippincott Williams & Wilkins; 2002. Chapter 2, pp. 9-26.
| Mailing Address
Section of Endocrine and Oncologic Surgery
Department of Surgery
Washington University School of Medicine
660 S. Euclid
Box 8109
St. Louis, MO 63110 |
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