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 | Haris Vikis Ph.D.
Cancer Prevention and Control
Research Assistant Professor of Surgery | Medical Education
Ph.D., Biochemistry, University of Michigan - Ann Arbor, MI, 2003.
Postdoctoral Study, Salk Institute - La Jolla, CA, 2004. | Selected or Recent Publications
Vikis H, Sato M, James M, Wang D, Wang Y et al. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Research. 2007;67(10):4665-4670.
Wang M, Zhang Z, Zhang Z, Vikis H, Yan Y, Wang Y, You M. Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. Cancer Research. 2007;67(6).
Wang M, Vikis HG, Wang Y et al. Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1 Cancer Research. 2007;67(1):93-99.
Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, Lubet RA, You M. Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. Molecular Cancer Research. 2006;4(12):971-981.
Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y, You M. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Nature Genetics. 2006;38(8):888-95. 2006 Jul 23. (co-first author)
Li Y, Inoki K, Vikis H, Guan KL. Measurements of TSC2 GAP Activity Toward Rheb. Methods in Enzymology. 2005;407:46-54.
Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nature Neuroscience. 2004;7(11):1213-1221. 2004 Oct 17.
Vikis HG, Guan KL. Glutathione-S-transferase-fusion based assays for studying protein-protein interactions. Methods in Molecular Biology. 2004;261:175-186.
Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Research. 2004;64(6):1924-1931.
Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Research. 2004;64(6):1924-1931.
Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL, You M. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proceedings of the National Academy of Sciences USA. 2003;100(22):12642-12647.
Chong H, Vikis HG, Guan KL. Mechanisms of regulating the Raf kinase family. Cellular Signalling. 2003;15(5):463-469.
Vikis H, Guan KL. Regulation of the Ras-MAPK pathway at the level of Ras and Raf. Genetic Engineering (NY). 2002;24:49-66.
Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. (co-first author) Proceedings of the National Academy of Sciences USA. 2002;99(19):12085-12090. 2002 Aug 26.
Vikis HG, Stewart S, Guan KL. SmgGDS displays differential binding and exchange activity towards different Ras isoforms. Oncogene. 2002;21(15):2425-2432. (co-first author)
Vikis HG, Li W, Guan KL. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes and Devopment. 2002;16(7):836-845.
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