physician photo

Paul E. Wise, MD

  • Professor of Surgery
  • Program Director, General Surgery Residency
  • Director, Inherited Colorectal Cancer and Polyposis Registry


Medical School

MD, Johns Hopkins University School of Medicine, Baltimore, MD, 1996

Post Doctoral Education

Categorical Resident in General Surgery, Vanderbilt University Medical Center, Nashville, TN, 1996-99, 2001-03

Research Resident, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, 1999-2001

Fellow in Colon and Rectal Surgery, Washington University School of Medicine, 2003-2004

Board Certifications

Colon and Rectal Surgery--Certified
General Surgery--Certified

Honors and Awards

  • 2012 Castle Connolly Medical Ltd. “America’s Top Doctor for Cancer” (8th Edition)
  • 2012 U.S. News and World Report and Castle Connolly Medical Ltd. “America’s Top Doctor” (12th Edition)
  • 2011 Castle Connolly Medical Ltd. “America’s Top Doctor for Cancer” (7th Edition)
  • 2011 U.S. News and World Report and Castle Connolly Medical Ltd. “America’s Top Doctor” (11th Edition)
  • 2009 The New Jersey Society of Colon and Rectal Surgeons Award for Best Poster for M’Koma A, Wise PE, Seeley E, Washington M, Schwartz D, Herline A, Muldoon R, Caprioli R. “Proteomic Patterns of Colonic Submucosa Discriminates Inflammatory Colitides” Awarded at the American Society of Colon and Rectal Surgeons Annual Scientific Meeting, Hollywood, FL, May 4, 2009.
  • 2003 Vanderbilt University J. William Hillman Award for the “resident deemed as the best teacher and role model by third and fourth year medical students”
  • 2003 Harwell Wilson Award for Excellence as Surgical Resident
  • 2002 Gold Medal Award winner, Southeastern Surgical Congress, for “Biliary reconstruction is enhanced with a collagen polyethylene glycol sealant”
  • 2002 Vanderbilt University Medical Student Housestaff Teaching Award
  • 2000 American Society of Transplantation Travel Award for Transplant, 2000, Chicago, IL
  • 1999 H. William Scott Surgical Research Award

Clinical Interests

Inherited colorectal cancer and hereditary colorectal cancer syndromes (Lynch syndrome, hereditary nonpolyposis colorectal cancer [HNPCC], familial adenomatous polyposis [FAP], polyposis syndromes)
Colon cancer
Rectal cancer
Anal cancer
Colon and rectal polyps
Inflammatory bowel disease (Crohn’s disease and ulcerative colitis)
Other disease of the colon and rectum (diverticulitis, benign and malignant disease of the anorectum)

Teaching Interests

Associate Program Director, Washington University Colon and Rectal Surgery Residency

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Patients Seen At

GI Center
Center for Advanced Medicine
4921 Parkview Place, Suite C, Floor 8
St. Louis, MO 63110
(314) 454-7177
Fax: (314) 454-5249

Barnes-Jewish West County Hospital
1040 North Mason Road
Professional Office Building One
Suite 120
St. Louis, MO 63141
(314) 454-7177
Fax: (314) 454-5249

Selected Publications

Rex DK, Ahnen DJ, Baron JA, Batts KP, Burke CA, Burt RW, Goldblum JR, Guillem JG, Kahi CJ, Kalady MF, O Brien MJ, Odze RD, Ogino S, Parry S, Snover DC, Torlakovic EE, Wise PE, Young J, Church J. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol. 2012 Sep;107(9):1315-29. PMID: 22710576

Geiger TM, Horst S, Muldoon R, Wise PE, Enrenfeld J, Poulose B, Herline AJ. Perioperative core body temperatures effect on outcome after colorectal resections. Am Surg. 2012 May;78(5):607-12. PMID: 22546136

Wise PE, Schwartz DA. The evaluation and treatment of Crohn perianal fistulae: EUA, EUS, MRI, and other imaging modalities. Gastroenterol Clin North Am. 2012 Jun;41(2):379-91. Review. PMID: 22500524

Weissman SM, Burt R, Church J, Erdman S, Hampel H, Holter S, Jasperson K, Kalady MF, Haidle JL, Lynch HT, Palaniappan S, Wise PE, Senter L. Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline. J Genet Couns. 2012 Aug;21(4):484-93. PMID: 22167527

M'Koma AE, Seeley EH, Washington MK, Schwartz DA, Muldoon RL, Herline AJ, Wise PE, Caprioli RM. Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides. Inflamm Bowel Dis. 2011;17(4):875-83.

O’Neil BH, Raftery L, Calvo BF, Chakravarthy AB, Ivanova A, Myers MO, Kim HJ, Chan E, Wise PE, Caskey LS, Bernard SA, Sanoff HK, Goldberg RM, Tepper JE. A phase I study of bortezomib in combination with standard 5-fluorouracil and external beam radiotherapy for the treatment of locally advanced or metastatic rectal cancer. Clinical Colorectal Cancer. 2010;9(2):119-25.

Delaney C, Marcello P, Sonoda T, Wise P, Bauer J, Techner L. Gastrointestinal recovery after laparoscopic partial large bowel resection: Results of a prospective, observational, multicenter study. Surg Endosc. 2010;24(3):653-61.

Rosen MJ, Moulton DE, Koyama T, Morgan WM 3rd, Morrow SE, Herline AJ, Muldoon RL, Wise PE, Polk DB, Schwartz DA. Endoscopic ultrasound to guide the combined medical and surgical management of pediatric perianal Crohn's disease. Inflamm Bowel Dis. 2010;16(3):461-8.

M’Koma AE, Wise PE, Muldoon RL, Schwartz DA, Herline AJ. Prevalence and outcome of anemia after restorative proctocolectomy: A clinical literature review. Dis Colon Rectum. 2009;52(4):726-39.

Spradlin NM, Wise PE, Herline AJ, Muldoon RL, Rosen M, Schwartz DA. A Randomized Prospective Trial of Endoscopic Ultrasound (EUS) to Guide Combination Medical and Surgical Treatment for Crohn’s Perianal Fistulas. Am J Gastroenterol. 2008;103(10):2527-35.

Dossett LA, White LM, Welch DC, Herline AJ, Muldoon RL, Schwartz DA, Wise PE. Small Bowel Adenocarcinoma Complicating Crohn’s Disease: Case Series and Review of the Literature. Am Surg. 2007;73(11):1181-7.

M'Koma AE, Wise PE, Muldoon RL, Schwartz DA, Washington MK, Herline AJ. Evolution of the Restorative Proctocolectomy and its effects on the Gastrointestinal Hormones. Int J Colorectal Dis. 2007;22(10):1143-63.

West NE, Wise PE, Herline AJ, Muldoon RL, Schwartz DA. Carcinoid Tumors are Fifteen Times More Common in Patients with Crohn’s Disease. Inflamm Bowel Dis. 2007;13(9):1129-34.

Coburn LA, Wise PE, Schwartz DA. The successful use of adalimumab to treat active Crohn's disease of an ileoanal pouch during pregnancy. Dig Dis Sci. 2006;51(11):2045-7.

Schwartz DA, White CM, Wise PE, Herline AJ. Use of endoscopic ultrasound to guide combination medical and surgical therapy for patients with Crohn's perianal fistulas. Inflamm Bowel Dis. 2005;11(8):727-32.

Click here for a link to Dr. Wise's Pub Med Page of publications.

Editorial Positions

Abstractor for the journal Diseases of the Colon and Rectum, 2008 – 2010
Ad hoc reviewer, Diseases of the Colon and Rectum
Ad hoc reviewer, Journal of the American College of Surgeons
Ad hoc reviewer, Annals of Surgery
Ad hoc reviewer, Surgery


Shepherd B, Wise PE, Schwartz D. How should patients be followed after successful treatment for rectal cancer? In: Adler DG (ed.). Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions. Thorofare, NJ: SLACK, Inc. (in press, 2010)

Wise PE. Total Proctocolectomy with Ileostomy: Hand Assisted. In: Fleshman JW, Wexner S (eds.). Master Techniques in Colon and Rectal Surgery. Philadelphia: Lippincott Williams & ilkins/Wolters Kluwer Health. in press, 2010)

Wise PE. Chapter 36: Polyps. In: Beck D, Senagore A, Roberts P, Wexner S (eds.). Saclarides T, Stamos M (eds.). ASCRS Textbook of Colon and Rectal Surgery. 2nd edition. New York: Springer. (in press, 2010)

Pierre K, Wise PE. Chapter 125: Loop Ileostomy and Colostomy. In: Resnick, Howards, McGuire, Preminger, and Smith, Jr. (eds.). Hinman's Atlas of Urologic Surgery. 3rd edition. Philadelphia: Elsevier. (submitted, 2008)

Wise PE, Schwartz DA. Management of Perianal Crohn’s Disease. Clin Gastroenterol Hepatol. 2006;4(4):426-30.

Wise PE, Kodner IJ. Surgical treatment of fecal incontinence. In: Bieber, Sanfillipo, Horowitz (eds.). Clinical Gynecology. Philadelphia: Elsevier; 2006.

Wise PE, Mutch MG. Hereditary nonpolyposis colorectal cancer. Semin Colon and Rectal Surgery 2004;15(3):136-46.

Wise PE, Holzman MD. Surgical anatomy of the gallbladder, liver, and biliary tree. In: MacFadyen B, Arregui M, Eubanks S, Peters JH, Soper NJ, Swanstrom LL (eds.). Laparoscopic Surgery of the Abdomen. New York: Springer-Verlag; 2003.

Chapman CW, Wright JK, Wise PE, Pinson CW. Techniques of exposure, hilar dissection, and parenchymal division in hepatic surgery. In: Pinson CW (ed.). Operative Techniques in General Surgery, 4(1): 13-32. Philadelphia: W.B. Saunders Company; March 2002.

Wise PE, Carr C, Donovan JE, Nagy R, Roman CD, Wudel JL. ABSITE Review 2001. Self-published, January 2001.

Wise PE, Pinson CW. Biliary complications of liver transplantation. In: Clavien P-A, Baillie JMB, Suhocki P (eds.). Diseases of the Gallbladder and Bile Ducts: Diagnosis and Treatment. Malden, MA:Blackwell Science; 2001.