William Gillanders

William E. Gillanders, MD

  • Professor of Surgery
  • Vice Chair for Research, Department of Surgery 

Medical School

Duke University School of Medicine, 1991

Post Doctoral Education

General Surgery Residency: Washington University School of Medicine, 1999.

Board Certifications

General Surgery -- Certified

Honors and Awards

National Institutes of Health K30 Clinical Research Curriculum Award, Medical University of South Carolina, 2003

National Cancer Institute K23 Research Career Award, Medical University of South Carolina, 2002

Samuel A. Wells Jr. Research Award, Washington University School of Medicine, 1999

National Institutes of Health Independent National Research Scientist Award, Washington University School of Medicine, 1994

Class of 1960 Scholar, Williams College, 1986

Clinical Interests

Breast cancer, surgical endocrinology, including minimally invasive endocrine surgery.

Research Interests

Antigen-specific T cell response to cancer vaccines.

Molecular detection of breast cancer in sentinel lymph nodes, peripheral blood and bone marrow of breast cancer patients.

Molecular targeting of EpCAM for breast cancer therapy.

Hospital Affiliations

Barnes-Jewish Hospital

Patients Seen At

Center for Advanced Medicine
Joanne Knight Breast Health Center
4921 Parkview Place, Suite F, Floor 5
St. Louis, MO 63110
(314) 362-2280

Contact Information

Washington University School of Medicine
Department of Surgery
Section of Endocrine and Oncologic Surgery
Campus Box 8109, 660 S. Euclid Ave.
St. Louis, MO 63110

Selected Publications

Mikhitarian K, Martin RH, Mitas M, Mauldin PD, Palesch Y, Metcalf JS, Cole DJ, Gillanders WE; Mims Study Group. Molecular analysis improves sensitivity of breast sentinel lymph node biopsy: results of a multi-institutional prospective cohort study. Surgery. 2005;138(3):474-481.

Mikhitarian K, Gillanders WE, Almeida JS, Hebert Martin R, Varela JC, Metcalf JS, Cole DJ, Mitas M. An innovative microarray strategy identities informative molecular markers for the detection of micrometastatic breast cancer. Clinical Cancer Research. 2005;11(10):3697-3704.

Salem ML, Kadima AN, Cole DJ, Gillanders WE. Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity. Journal of Immunotherapy. 2005;28(3):220-228.

Mitas M, Almeida JS, Mikhitarian K, Gillanders WE, Lewin DN, Spyropoulos DD, Hoover L, Graham A, Glenn T, King P, Cole DJ, Hawes R, Reed CE, Hoffman BJ. Accurate discrimination of Barrett's esophagus and esophageal adenocarcinoma using a quantitative three-tiered algorithm and multimarker real-time reverse transcription-PCR. Clinical Cancer Research. 2005;11(6):2205-2214.

Yan Y, Rubinchik S, Watson PM, Kelley JR, Fraser MM, Wood AL, Dong JY, Gillanders WE, Boylan AM, Watson DK, Cole DJ. Establishing a murine pancreatic cancer CaSm model: up-regulation of CaSm is required for the transformed phenotype of murine pancreatic adenocarcinoma. Molecular Therapy. 2005;11(3):363-372.

Harper JL, Jenrette JM, Vanek KN, Aguero EG, Gillanders WE. Acute complication of MammoSite brachytherapy, a single institution’s initial clinical experience. International Journal of Radiation Oncology, Biology and Physics. 2005; 61:169.

Osta W, Chen Y, Mikhitarian K, Mitas M, Salem M, Cole DJ, Gillanders WE. EpCAM is a valuable molecular marker for metastatic breast cancer and a potential target for breast cancer gene therapy. Cancer Research. 2004;64:5818.

Taha T, Osta W, Kozhaya L, Bielawski J, Johnson KR, Gillanders WE, Dbaibo GS, Hannun YA, Obeid LM. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. Journal of Biological Chemistry. 2004;279:20546-20554.

Gillanders WE, Mikhitarian K, Hebert R, Mauldin PD, Palesch Y, Urist MM, Mann BG, Doherty G, Herrmann VM, Hill AD, Eremin O, Orr RK, Steinberg S, Valle AA, Henderson MA, Adams-Campell L, Sugg SL, Frykberg E, Yeh K, Bell RM, Metcalf JS, Elliott B, Brothers T, Robison J, Mitas M, Cole DJ. Molecular detection of micrometastatic breast cancer in pathology-negative axillary lymph nodes correlates with traditional predictors of prognosis: an interim analysis of a prospective multi-institutional cohort study. Annals of Surgery. 2004;239:828-837.

Salem ML, Kadima AN, Zhou Y, Nguyen CL, Rubinstein MP, Demcheva M, Vournakis JN, Cole DJ, Gillanders WE. Paracrine release of IL-12 stimulates IFN-gamma production and dramatically enhances the antigen-specific T cell response after vaccination with a novel peptide-based cancer vaccine. Journal of Immunology. 2004;172:5159-5167.

Mikhitarian K, Reott S, Hoover L, Allen A, Cole DJ, Gillanders WE, Mitas M. Enhanced detection of RNA from paraffin-embedded tissue using a panel of truncated gene-specific primers for reverse transcription. Biotechniques. 2004;36:474-478.

Baker MK, Mikhitarian K, Osta W, Callahan K, Hoda R, Brescia F, Kneuper-Hall R, Mitas M, Cole DJ, Gillanders WE. Molecular detection of breast cancer cells in the peripheral blood of advanced-stage breast cancer patients using multimarker real-time reverse transcription-polymerase chain reaction and a novel porous barrier density gradient centrifugation technology. Clinical Cancer Research. 2003;9:4865-4871.

Mitas M, Hoover L, Silvestri G, Reed C, Green M, Turrisi AT, Sherman C, Mikhitarian K, Cole DJ, Block MI, Gillanders WE. Lunx is a superior molecular marker for detection of non-small cell lung cancer in peripheral blood. Journal of Molecular Diagnostics. 2003;5:237-242.

Rubinstein MP, Kadima AN, Nguyen CL, Nishimura MI, Gillanders WE, Cole DJ. Maintenance of parental T cell avidity following TCR gene transfer into mature T cells. Journal of Immunology. 2003;170:1217.

Rubinstein MP, Kadima AN, Mohamed SL, Nguyen CL, Gillanders WE, Cole DJ. Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells. Journal of Immunology. 2002;169:4928-4935.

Pub Med for William E. Gillanders, M.D.