Division of Public Health Sciences
Department of Surgery
Dr. Chang is a health economist and an applied econometrician. Dr. Chang’s research focuses on health and economic consequences of obesity and surgical treatments of obesity. Her research uses economic and econometric/statistical modeling to evaluate program and treatment effects. Dr. Chang’s research areas include treatment effect and policy evaluation, cost-effectiveness analysis, meta-analysis, and comparative effectiveness.
Dr. Chang teaches “Decision Analysis for Clinical Investigation and Economic Evaluation" in the Master of Population Health Sciences program.
Xiaoyan Liu, Statistical Data Analyst
Suhong Luo, Statistical Data Analyst
Chang S-H, Luo S, Thomas TS, O’Brian KK, Colditz GA, Carlsson NP, Carson KR. Obesity and the transformation of monoclonal gammopathy of undetermined significance to multiple myeloma: a population-based cohort study. Journal of the National Cancer Institute (In press).
Leung M, Carlsson NP, Colditz GA, Chang S-H. The burden of obesity on diabetes in the United States: Medical Expenditure Panel Survey, 2008-2012. Value in Health. 2016 Nov 4. [Epub ahead of print]
Alhamad T, Malone AF, Brennan DC, Stratta RJ, Chang S-H, Wellen JR, Horwedel TA, Lentine KL. Transplant center volume and the risk of pancreas allograft failure. Transplantation. 2016 Jul 15. [Epub ahead of print]
Alhamad T, Malone AF, Lentine KL, Brennan DC, Wellen J, Chang S-H, Chakkera HA. Selected mildly obese donors can be used safely in simultaneous pancreas and kidney transplantation. Transplantation, 2016; Jul 15. doi: 10.1097/TP.0000000000001303.
Yaghjyan L, Carlsson NP, Ghita GL, Chang S-H. Associations of individual characteristics and lifestyle factors with metabolism of di-2-ethylhexyl phthalate in NHANES 2001-2012. Environmental Research, 2016; Aug;149:23-31. doi: 10.1016/j.envres.2016.05.002. Epub 2016 May 9.
Yaghjyan L, Sites S, Ruan Y, Chang S-H. Associations of Urinary Phthalates with Body Mass Index, Waist Circumference, and Serum Lipids Among Females: National Health and Nutrition Examination Survey 1999-2004. International Journal of Obesity, 2015; 39: 994-1000.
Chang S-H, Luo S, O’Brian KK, Thomas TS, Colditz GA, Carlsson NP, Carson KR. Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study. The Lancet Haematology, 2015;2:30-36.
Leung M, Pollack LM, Colditz GA, Chang S-H. Life years lost and lifetime healthcare expenditures associated with diabetes in the U.S., National Health Interview Survey, 1997–2000. Diabetes Care, 2015;38:1-9.
Chang S-H, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA. The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012. JAMA surgery. 2014 Mar;149(3):275-87. doi: 10.1001/jamasurg.2013.3654. Click here for supplemental material, including review protocol and additional articles.
Chang S-H, Pollack LM, Colditz GA. Obesity, mortality, and life years lost associated with breast cancer in nonsmoking U.S. women, National Health Interview Survey, 1997–2000. Preventing Chronic Disease. 2013 Nov 14;10:E186. doi: 10.5888/pcd10.130112.
Beason TS, Chang S-H, Sanfilippo KM, Luo S, Colditz GA, Vij R, Tomasson MH, Dipersio JF, Stockerl-Goldstein K, Ganti A, Wildes T, Carson KR. Influence of body mass index on survival in veterans with multiple myeloma. Oncologist. 2013;18(10):1074-9. doi: 10.1634/theoncologist.2013-0015. Epub 2013 Sep 18.
Chang S-H, Pollack LM, Colditz GA. Life years lost associated with obesity-related diseases for U.S. nonsmoking adults. PLoS ONE 8(6): e66550. doi:10.1371/journal.pone.0066550.
Carson KR, Bartlett NL, McDonald JR, Luo S, Zeringue A, Liu J, Fu Q, Chang S-H, Colditz GA. Increased body mass index is associated with improved survival in united states veterans with diffuse large B-cell lymphoma. Journal of Clinical Oncology. 2012 Sep; 30(26):3217-22.
Chang S-H, Beason TS, Hunleth JM, Colditz GA. A systematic review of body fat distribution and mortality in older people. Maturitas. 2012 Jul;72(3):175-91.
Chang S-H, Stoll CR, Colditz GA. Cost-effectiveness of bariatric surgery: should it be universally available? Maturitas. 2011 Jul;69(3):230-8.
Dr. Chang on PubMed
Grants and Projects
Agency for Healthcare Research and Quality
K01 HS022330 (Chang: PI) 09/30/13 – 9/29/17
Obesity, comorbidities, and economic evaluations of surgical treatments of obesity
The objective of this project is to systematically investigate the interplay of obesity, comorbidities, and all-cause mortality focusing on how surgical treatments can alter this relationship. The project evaluates different types of bariatric surgery from a population perspective with the goals of identifying the optimal surgical procedure for each obese population and assessing the current NIH guidelines on the eligibility of bariatric surgery.
Role: Principal Investigator
National Institutes of Health
U54 CA 155496 (Colditz: PI) 05/01/13 – 6/30/14
Washington University in St. Louis Transdisciplinary Research on Energetics and Cancer Center
Influence of Obesity and Metformin Use on the Transformation of Monoclonal Gammopathy of Undetermined Significance into Multiple Myeloma
The objective of this project is to examine the relationships between obesity, metformin use, and progression from monoclonal gammopathy of undetermined significance to multiple myeloma in a large cohort of the U.S. veterans. Econometric methods that account for potential bias arising from observational data will be used to explore the relationships.
Role: Principal Investigator
National Institutes of Health
KM1 CA156708 (Fraser: PI) 06/01/12 – 08/31/13
Washington University CER Mentored Career Development Award Program
Comparative Effectiveness of Bariatric Surgery: A Meta-Analysis
The goal of the proposed research is to closely examine the comparative effectiveness of different types of bariatric surgery by evaluating: (1) the risks – peri- and post-operative mortality, complications, and reoperations; and (2) the lifetime benefits – weight loss and remission of obesity-related diseases.