Portrait of Ghazaleh Pourali, MD

Ghazaleh Pourali, MD

Assistant Professor of Surgery
Division of Public Health Sciences

Specialties

  • Epidemiology 
  • Cancer disparities 
  • Breast cancer prevention 
  • Cancer risk 
  • Randomized controlled trials 
  • Metabolomics 
  • Lipidomics 
  • Proteomics 

Meet Dr. Pourali 

Dr. Ghazaleh Pourali is an epidemiologist specializing in breast cancer epidemiology. 

She has expertise in designing and implementing analytical plans. 

Dr. Pourali earned her medical degree from Mashhad University of Medical Sciences. She completed a postdoctoral fellowship at WashU Medicine.  


Degrees

Medical Degree
Mashhad University of Medical Sciences, Mashhad, Iran
2021

Fellowship

Metabolic Syndrome Research Fellowship
Mashhad University of Medical Sciences, Mashhad, Iran
2023


Research interests

Cancer biomarker discovery, 

Breast cancer risk 

Breast density 

Metabolomics 

Lipidomics 

Proteomics 

Targeted prevention via dietary, lifestyle, and chemopreventative interventions 

Interventional trial design 

Precision oncology 


More information

Reviews, Editorials, and Invited Publications

1 Pourali G, Toriola AT. The untapped opportunities of addressing lifecourse growth in mammographic breast density and breast cancer prevention in non-Hispanic Black women. Cancer Epidemiol Biomarkers Prev. 2024. 33(12): 1541-1543. [Invited Commentary] 

2 Goleij P, Pourali G, Raisi A, Ravaei F, Golestan S, Abed A, Razavi ZS, Zarepour F, Taghavi SP, Ahmadi Asouri S, Rafiei M. Role of non-coding RNAs in the response of glioblastoma to temozolomide. Mol Neurobiol. 2025. 62(2): 1726-1755. 

3 Sahranavard T, Mehrabadi S, Pourali G, Maftooh M, Akbarzade H, Hassanian SM, Mobarhan MG, Ferns GA, Khazaei M, Avan A. The potential therapeutic applications of CRISPR/Cas9 in colorectal cancer. Curr Med Chem. 2024. 31(35): 5768-5778. 

4 Pourali G, Zafari N, Fiuji H, Batra J, Nazari E, Khazaei M, Hassanian SM, Vahabi M, Kiani M, Ghayour-Mobarhan M, Peters GJ. Extracellular vesicles: emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities. Cytokine Growth Factor Rev. 2024. 73: 101-113. 

5 Pourali G, Ahmadzade AM, Arastonejad M, Pourali R, Kazemi D, Ghasemirad H, Khazaei M, Fiuji H, Nassiri M, Hassanian SM, Ferns GA. The circadian clock as a potential biomarker and therapeutic target in pancreatic cancer. Mol Cell Biochem. 2024. 479(5): 1243-1255.  

6 Pourali G, Kazemi D, Chadeganipour AS, Arastonejad M, Kashani SN, Pourali R, Maftooh M, Akbarzade H, Fiuji H, Hassanian SM, Ghayour-Mobarhan M, et al. Microbiome as a biomarker and therapeutic target in pancreatic cancer. BMC Microbiol.2024. 24(1): 16. 

7 Ahmadzadeh AM, Pourali G, Mirheidari SB, Shirazinia M, Hamedi M, Mehri A, Amirbeik H, Saghebdoust S, Tayarani-Najaran Z, Sathyapalan T, Forouzanfar F. Medicinal plants for the treatment of neuropathic pain: a review of randomized controlled trials. Curr Pharm Biotechnol. 2024. 25(5): 534-562. 

8 Pourali G, Zafari N, Velayati M, Mehrabadi S, Maftooh M, Hassanian SM, GhayourMobarhan M, Ferns GA, Avan A, Khazaei M. Therapeutic potential of targeting TGFbeta and PD-L1 in pancreatic cancer. Curr Drug Targets. 2023. 24(17): 1335-1345. 

9 Pourali G, Kazemi D, Pourali R, Rahmani N, Razzaghi E, Maftooh M, Fiuji H, Ghorbani E, Khazaei M, Ferns GA, Hassanian SM. Bioactive peptides: potential impact on the treatment of gastrointestinal cancers. Curr Pharm Des. 2023. 29(31): 2450-2460. 

10 Rahmani N, Pourali G, Hosseini N, Fiuji H, Maftooh M, Hassanian SM, Ferns GA, Khazaei M, Avan A. Probiotics as a therapeutic approach in colorectal cancer. Curr Cancer Drug Targets. 2023. 23(10): 764-777. 

11 Pourali G, Khalili-Tanha G, Nazari E, Maftooh M, Nassiri M, Hassanian SM, Mobarhan MG, Khazaei M, Ferns G, Avan A. Circulating tumor cells and cell-free nucleic acids as biomarkers in colorectal cancer. Curr Pharm Des. 2023. 29(10): 748-765. 

12 Pourali G, Hosseini ZS, Maftooh M, Nazari E, Khazaei M, Nassiri M, Hassanian SM, Ghayour-Mobarhan M, Ferns GA, Kiani MA, Avan A. Therapeutic potential of herbal medicine against non-alcoholic fatty liver disease. Curr Drug Targets. 2023. 24(4): 300-319. 

13 Zafari N, Velayati M, Damavandi S, Pourali G, Mobarhan MG, Nassiri M, Hassanian SM, Khazaei M, Ferns GA, Avan A. Metabolic pathways regulating colorectal cancer: a potential therapeutic approach. Curr Pharm Des. 2022. 28(36): 2995-3009. 

14 Zafari N, Velayati M, Fahim M, Maftooh M, Pourali G, Khazaei M, Nassiri M, Hassanian SM, Ghayour-Mobarhan M, Ferns GA, Kiani MA. Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: molecular mechanisms, biomarkers, and therapeutic perspective. Life Sci. 2022. 305: 120760. 

15 Samami E, Pourali G, Arabpour M, Fanipakdel A, Shahidsales S, Javadinia SA, Hassanian SM, Mohammadparast S, Avan A. The potential diagnostic and prognostic value of circulating microRNAs in the assessment of patients with prostate cancer. Front Oncol. 2022. 11: 716831. 

16 Salmaninejad A, Pourali G, Shahini A, Darabi H, Azhdari S. MicroRNA and exosome in retinal-related diseases: their roles in the pathogenesis and diagnosis. Comb Chem High Throughput Screen. 2022. 25(2): 211-228.

Collaborative Global Burden of Disease (GBD) Publications

1. Schumacher AE, Kyu HH, … Pourali G, et al. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic. The Lancet. 2024. 403(10440): 1989-2056.  

2. Bhattacharjee NV, Schumacher AE, … Pourali G, et al. Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100. The Lancet. 2024. 403(10440): 2057-2099.  

3. Sharma R, Abbastabar H, … Pourali G, et al. Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study. The Lancet Regional Health-Southeast Asia. 2024. 21: 100333.  

4. Ong KL, Stafford LK, … Pourali G, et al. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050. The Lancet. 2023. 402(10397): 203-234.  

5. Mensah GA, Fuster V, … Pourali G, et al. Global burden of cardiovascular diseases and risks, 1990-2022. Journal of the American College of Cardiology. 2023. 82(25): 2350-2473. 

6. Moberg ME, Hamilton EB, … Pourali G, et al. Global, regional, and national mortality due to unintentional carbon monoxide poisoning, 2000–2021. The Lancet Public Health. 2023. 8(11): e839-e849.  

7. Nejadghaderi SA, Saeedi Moghaddam S, … Pourali G, et al. Trends of national and subnational burden attributed to kidney dysfunction risk factor in Iran: 1990-2019. Frontiers in Endocrinology. 2023. 14: 1115833.  

Book Chapters

1. Pourali G, Donyadideh G, Mehrabadi S, Fiuji H, Hassanian SM, Ferns GA, Khazaei M, Avan A. Clinical practice guidelines for interventional treatment of pancreatic cancer. In: Recent Advances in Nanocarriers for Pancreatic Cancer Therapy. Academic Press; 2024. pp. 345-373. [Invited chapter] 

2. Pourali G, Rajabloo Y, Hosseini N, Maftooh M, Ghayour-Mobarhan M, Soleimanpour S, Hassanian SM, Ferns GA, Kiani MA, Khazaei M, Avan A. Cancer precision medicine: focus on gastrointestinal cancer. In: Biomaterials for Precision Cancer Medicine. Elsevier Science Ltd; 2025. pp. 27-68. [Invited chapter] 

Manuscripts in Preparation

1. Pourali G, Jeon MS, Liberty A, Luo C, Hagemann AR, Luo J, Toriola AT. Oral contraceptive use and steroid hormone metabolites in premenopausal women. Under review. 

2. Pourali G, Lyu L, Guo X, Toriola AT. Genetically predicted metabolites and their association with mammographic breast density and breast cancer risk. In preparation. Results presented at SABCS 2025.