Mathieu Garand, PhD

Mathieu Garand, PhD

Instructor of Surgery

Expertise

Specialty Areas

  • Pediatric Cardiothoracic Surgery
Education

Degrees

BS, Biochemistry, University of Sherbrooke, Sherbrooke, Quebec, Canada

MSc, Biochemistry, Queen’s University, Kingston, Ontario, Canada

PhD, Biochemistry, Queen’s University, Kingston, Ontario, Canada

Fellowship

Postdoctoral Fellowship, University of Windsor, Windsor, Ontario, Canada

Postdoctoral Fellowship, Children’s Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

Professional Memberships

Federation of Clinical Immunology Societies

European Society for Pediatric Infectious Diseases

Awards and Honors

2014, FOCIS Advanced Course in Basic & Clinical Immunology Award
2014 – 2016, E.G. Bauman Award, Queen’s University
2015, CIHR travel award Conferences/Workshop
2015, Graduates’ Choice Teaching Excellence Award

Research

Areas of Research Interest

  • Translational research focused on improving prevention and treatments for immunopathology and infectious diseases in neonates and young infants
  • Immune responses in neonates following surgery
  • Identifying factors contributing to the pathogenesis of congenital heart disease as well as their specific mechanisms
  • Assessing the relationship between viral infection and congenital heart disease

Publications

Journal Articles

  1. Garand M, Bastajian N, Nesheim ME, Boffa MB, Koschinsky ML. Molecular analysis of the human thrombin-activatable fibrinolysis inhibitor gene promoter. Br J Haematol. 2007;138(2):231-44. PMID:17593031
  2. Garand M, Lin JH, Hill CE, Zagorac B, Koschinsky ML, Boffa MB. Regulation of the mouse gene encoding TAFI by TNFα: role of NFκB binding site. Cytokine. 2012;57(3):389-97. PMID:22217421
  3. Garand M, Lin JH, Zagorac B, Koschinsky ML, Boffa MB. Regulation of the gene encoding human thrombin-activatable fibrinolysis inhibitor by estrogen and progesterone. Blood Coagul Fibrinolysis. 2013;24(4):393-404. PMID:23429253
  4. Lin JH, Novakovic D, Rizzo CM, Zagorac B, Garand M, Filipieva A, Koschinsky ML, Boffa MB. The mRNA encoding TAFI is alternatively spliced in different cell types and produces intracellular forms of the protein lacking TAFIa activity. Thromb Haemost. 2013;109(6):1033-44. PMID:23595589
  5. Garand M, Cai B, Kollmann TR. Environment impacts innate immune ontogeny. Innate Immun. 2017;23(1):3-10. PMID:27697850
  6. Marchant A, Sadarangani M, Garand M, Dauby N, Verhasselt V, Pereira L, Bjornson G, Jones CE, Halperin SA, Edwards KM, Heath P, Openshaw PJ, Scheifele DW, Kollmann TR. Maternal immunisation: collaborating with mother nature. Lancet Infect Dis. 2017;17(7):e197-e208. PMID:28433705
  7. Coulter F, Parrish A, Manning D, Kampmann B, Mendy J, Garand M, Lewinsohn DM, Riley EM, Sutherland JS. IL-17 Production from T Helper 17, Mucosal-Associated Invariant T, and γδ Cells in Tuberculosis Infection and Disease. Front Immunol. 2017;8:1252. PMCID:PMC5641565 PMID:29075255
  8. Garand M, Goodier M, Owolabi O, Donkor S, Kampmann B, Sutherland JS. Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease. Front Immunol. 2018;9:257. PMCID:PMC5827559 PMID:29520269
  9. Huang SSY, Al Ali F, Boughorbel S, Toufiq M, Chaussabel D, Garand M. A curated collection of transcriptome datasets to investigate the molecular mechanisms of immunoglobulin E-mediated atopic diseases. Database (Oxford). 2019;2019. PMCID:PMC6616200 PMID:31290545
  10. Roelands J, Garand M, Hinchcliff E, Ma Y, Shah P, Toufiq M, Alfaki M, Hendrickx W, Boughorbel S, Rinchai D, Jazaeri A, Bedognetti D, Chaussabel D. Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature. Front Immunol. 2019;10:2410. PMCID:PMC6813721 PMID:31681299
  11. Kumar M, Garand M, Al Khodor S. Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine. J Transl Med. 2019;17(1):419. PMCID:PMC6909475 PMID:31836022
  12. Garand M, Kumar M, Huang SSY, Al Khodor S. A literature-based approach for curating gene signatures in multifaceted diseases. J Transl Med. 2020;18(1):279. PMCID:PMC7350750 PMID:32650786
  13. Rinchai D, Syed Ahamed Kabeer B, Toufiq M, Tatari-Calderone Z, Deola S, Brummaier T, Garand M, Branco R, Baldwin N, Alfaki M, Altman MC, Ballestrero A, Bassetti M, Zoppoli G, De Maria A, Tang B, Bedognetti D, Chaussabel D. A modular framework for the development of targeted Covid-19 blood transcript profiling panels. J Transl Med. 2020;18(1):291. PMCID:PMC7393249 PMID:32736569
  14. Tomei S, Singh P, Mathew R, Mattei V, Garand M, Alwakeel M, Sharif E, Al Khodor S. The Role of Polymorphisms in Vitamin D-Related Genes in Response to Vitamin D Supplementation. Nutrients. 2020;12(9). PMCID:PMC7551134 PMID:32867112
  15. Huang SSY, Makhlouf M, AbouMoussa EH, Ruiz Tejada Segura ML, Mathew LS, Wang K, Leung MC, Chaussabel D, Logan DW, Scialdone A, Garand M, Saraiva LR. Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting. Mol Metab. 2020;40:101038. PMCID:PMC7339127 PMID:32526449
  16. Rawat A, Rinchai D, Toufiq M, Marr AK, Kino T, Garand M, Tatari-Calderone Z, Kabeer BSA, Krishnamoorthy N, Bedognetti D, Karim MY, Sastry KS, Chaussabel D. A Neutrophil-Driven Inflammatory Signature Characterizes the Blood Transcriptome Fingerprint of Psoriasis. Front Immunol. 2020;11:587946. PMCID:PMC7732684 PMID:33329570
  17. Toufiq M, Roelands J, Alfaki M, Syed Ahamed Kabeer B, Saadaoui M, Lakshmanan AP, Bangarusamy DK, Murugesan S, Bedognetti D, Hendrickx W, Al Khodor S, Terranegra A, Rinchai D, Chaussabel D, Garand M. Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data. Immunology. 2020;161(4):291-302. PMCID:PMC7692248 PMID:32682335
  18. Rinchai D, Altman MC, Konza O, Hässler S, Martina F, Toufiq M, Garand M, Kabeer BSA, Palucka K, Mejias A, Ramilo O, Bedognetti D, Mariotti-Ferrandiz E, Klatzmann D, Chaussabel D. Definition of erythroid cell-positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection. Clin Transl Med. 2020;10(8):e244. PMCID:PMC7733317 PMID:33377660
  19. Le Berre L, Chesneau M, Danger R, Dubois F, Chaussabel D, Garand M, Brouard S. Connection of BANK1, Tolerance, Regulatory B cells, and Apoptosis: Perspectives of a Reductionist Investigation. Front Immunol. 2021;12:589786. PMCID:PMC8015775 PMID:33815360
  20. Sawyer AJ, Garand M, Chaussabel D, Feng CG. Transcriptomic Profiling Identifies Neutrophil-Specific Upregulation of Cystatin F as a Marker of Acute Inflammation in Humans. Front Immunol. 2021;12:634119. PMCID:PMC8047108 PMID:33868254
  21. Garand M, Toufiq M, Singh P, Huang SSY, Tomei S, Mathew R, Mattei V, Al Wakeel M, Sharif E, Al Khodor S. Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population. Int J Mol Sci. 2021;22(9). PMCID:PMC8126205 PMID:34068701
  22. Altman MC, Rinchai D, Baldwin N, Toufiq M, Whalen E, Garand M, Syed Ahamed Kabeer B, Alfaki M, Presnell SR, Khaenam P, Ayllón-Benítez A, Mougin F, Thébault P, Chiche L, Jourde-Chiche N, Phillips JT, Klintmalm G, O’Garra A, Berry M, Bloom C, Wilkinson RJ, Graham CM, Lipman M, Lertmemongkolchai G, Bedognetti D, Thiebaut R, Kheradmand F, Mejias A, Ramilo O, Palucka K, Pascual V, Banchereau J, Chaussabel D. Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data. Nat Commun. 2021;12(1):4385. PMCID:PMC8289976 PMID:34282143
  23. Huang SSY, Toufiq M, Saraiva LR, Van Panhuys N, Chaussabel D, Garand M. Transcriptome and Literature Mining Highlight the Differential Expression of ERLIN1 in Immune Cells during Sepsis. Biology (Basel). 2021;10(8). PMCID:PMC8389572 PMID:34439987
  24. Toufiq M, Huang SSY, Boughorbel S, Alfaki M, Rinchai D, Saraiva LR, Chaussabel D, Garand M. SysInflam HuDB, a Web Resource for Mining Human Blood Cells Transcriptomic Data Associated with Systemic Inflammatory Responses to Sepsis. J Immunol. 2021;207(9):2195-2202. PMCID:PMC8525868 PMID:34663591
  25. Huang SSY, Rinchai D, Toufiq M, Kabeer BSA, Roelands J, Hendrickx W, Boughorbel S, Bedognetti D, Van Panhuys N, Chaussabel D, Garand M. Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis. J Cell Mol Med. 2022;26(5):1714-1721. PMCID:PMC8899167 PMID:35174610
  26. Brown LG, Haack AJ, Kennedy DS, Adams KN, Stolarczuk JE, Takezawa MG, Berthier E, Thongpang S, Lim FY, Chaussabel D, Garand M, Theberge AB. At-home blood collection and stabilization in high temperature climates using homeRNA. Front Digit Health. 2022;4:903153. PMCID:PMC9405416 PMID:36033636
  27. Garand M, Huang SSY, Goessling LS, Santillan DA, Santillan MK, Brar A, Wylie TN, Wylie KM, Eghtesady P. A Case of Persistent Human Pegivirus Infection in Two Separate Pregnancies of a Woman. Microorganisms. 2022;10(10). PMCID:PMC9610878 PMID:36296201
  28. Garand M, Huang SSY, Goessling LS, Wan F, Santillan DA, Santillan MK, Brar A, Wylie TN, Wylie KM, Eghtesady P. Virome Analysis and Association of Positive Coxsackievirus B Serology during Pregnancy with Congenital Heart Disease. Microorganisms. 2023;11(2). PMCID:PMC9963073 PMID:36838226
  29. Preechanukul A, Yimthin T, Tandhavanant S, Brummaier T, Chomkatekaew C, Das S, Syed Ahamed Kabeer B, Toufiq M, Rinchai D, West TE, Chaussabel D, Chantratita N, Garand M. Abundance of ACVR1B transcript is elevated during septic conditions: Perspectives obtained from a hands-on reductionist investigation. Front Immunol. 2023;14:1072732. PMCID:PMC10067751 PMID:37020544