Grace M. Niziolek, MD

Grace M. Niziolek, MD

Assistant Professor of Surgery


Specialty Areas

  • General surgery
  • Surgical critical care

Common Procedures & Diagnoses Treated

  • Appendicitis
  • Cholecystitis
  • Hernia
  • Bowel obstructions
  • Diverticulitis
  • Soft tissue infections
  • Trauma
  • Abdominal wall reconstruction
  • Sepsis
  • Multiple organ dysfunction
  • Septic shock
  • Chest wall reconstruction
  • Skin and soft tissue reconstruction
  • Necrotizing soft tissue infections
  • Pancreatitis
  • Gastrointestinal bleeding
  • Thermal injuries
  • Wound care
  • Respiratory distress
  • Enterocutaneous fistulas

Board Certifications

General Surgery
Surgical Critical Care
Trauma and Acute Care Surgery


Medical School: University of North Carolina at Chapel Hill, Chapel Hill, NC, 2014


Internship and General Surgery Residency, University of Cincinnati, Cincinnati, OH, 2014-2021


Surgical Research Fellowship, University of Cincinnati, Cincinatti, OH, 2016-2018

Trauma, Critical Care, and Acute Care Surgery Fellowship, Hospital of the University of Pennsylvania, Philadelphia, PA, 2023

Professional Memberships

American College of Surgeons
Association of Academic Surgeons
Society of Critical Care Medicine
American Association for the Surgery of Trauma

Awards and Honors

2014, Gold Humanism Award
2015, 2021, Winner, Best Resident Teacher Award; given by the UC Medical Students
2018, Finalist, Committee on Trauma National Resident Paper Award
2018, Winner, Region 5 Committee on Trauma Resident Paper Award
2018, Winner, Ohio Committee on Trauma Resident Paper Award
2018, Shock Society Travel Award
2018, Finalist, Young Investigator Award, Shock Society
2018, Winner, University of Cincinnati Acute Care Research Resident of the Year
2019, Winner, AAST Best Critical Care Paper
2020, 2021, Finalist, Herbst Trauma Resident of the Year Award
2021, Finalist, Max Zinninger Award, University of Cincinnati, Department of Surgery
2021, Finalist, Excellence in Advanced Laparoscopy Award, University of Cincinnati
2021, Winner, Joseph Fischer Award, University of Cincinnati, Department of Surgery


Areas of Research Interest

Traumatic brain injury, coagulopathy of critical illness and trauma, platelet dysfunction


Niziolek GM, Dowzicky P, Joergensen S, Zone A, Brinson M, Martin N, Seamon MD, Raza S, Yelon J, Cannon J. Brief report on the development of hemorrhagic pericardial effusion following thoracic surgery for traumatic injuries. Trauma and Acute Care Open. 2023 8(1):e001090.

Niziolek GM, Keating J, Bailey J, Klingensmith NJ, Moren AM, Skarupa DJ, Loria A, Vella MA, Maher Z, Moore SA, Smith MC, Leung A, Shuster KM, Seamon MJ. Rethinking protocolized completion angiography following extremity vascular trauma: A prospective observational multicenter trial. J Trauma Acute Care Surg. 2023, 95:105-110.

Culkin M, Bele P, Georges AT, Lopez AJ, Niziolek GM, Jacovides CL, Song H, Johnson VE, Kaplan L, Smith DH, Pascual JL. Early post-traumatic brain injury TXA prevents blood brain barrier hyperpermeability and surrogates of neuroclinical recovery. J Trauma Acute Care Surg. 2023, 95:47-54.

Niziolek GM, Smith BP, Cannon J, Yelon J. Management of a common hepatic artery pseudoaneurysm following blunt trauma. Trauma Acute Care Surg Open. 2022; 7:e000909.

Niziolek GM, Goodman MD, Makley A, Millar DA, Heh V, Pritts TA, Janowak C. Early results after initiation of rib fixation programme: A propensity score matched analysis. Injury. 2021 doi:10.1016/j.injury.2021.09.009

Niziolek GM, Hoehn RS, Seitz AP, Boudreau RM, Jernigan PL, Makley AT, Gulbins E, Edwards MJ, Goodman MD. The role of acid sphingomyelinase inhibition in repetitive mild traumatic brain injury. J Surg Res. 2021; 259:296-304.

Niziolek GM, Boudreau RM, Baker J, Friend LA, Makley AT, Edwards MJ, Gulbins E, Goodman MD. Acid sphingomyelinase inhibition mitigates histopathologic and behavioral changes in a murine model of traumatic brain injury. J Neurotrauma. 2020; 37(17):1902-9.

Morris MC, Singer KE, Niziolek GM, McGlone E, Veile R, Friend LA, Makely AT, Goodman MD. Post-injury oxygenation extremes transiently affect coagulation. Thromb Res. 2020; 186:58-63.

Morris MC, Bercz A, Niziolek GM, Kassam F, Veile R, Friend LA, Pritts TA, Makley AT, Goodman MD. UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma. J Surg Res. 2019; 244:63-68.

Morris MC, Niziolek GM, Baker JE, Huebner BR, Hanseman D, Makley AT, Pritts TA, Goodman MD. Death by decade: establishing a transfusion ceiling for futility in massive transfusion. J Surg Res. 2020; 252:139-46.

Morris MC, Niziolek GM, Blakeman TC, Stevens-Topie S, Veile R, Heh V, Zingarelli B, Rodriguez D, Branson RD, Goodman MD. Intrathoracic pressure regulator performance in the setting of hemorrhage and acute lung injury. Mil Med. 2020; 185(7-8):e1083-1090.

Baker JE, Niziolek GM, Elson NC, Pugh AM, Nomellini V, Makley AT, Pritts TA, Goodman MD. Optimizing lower extremity duplex ultrasound screening after traumatic injury. J Surg Res. 2019 243:143-150.

Martin GE, Pugh A, Williams SG, Hanseman D, Nomellini V, Makley AT, Pritts TA, Goodman MD. Lower extremity duplex ultrasound screening protocol for moderate and high risk trauma patients. J Surg Res. 2019 235:280-287.

Martin GE, Pugh AM, Moran R, Veile R, Friend LA, Pritts TA, Makley AT, Caldwell, C, Goodman MD. Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine diphosphate receptor. J Trauma Acute Care Surg. 2019 86(4): 592-600.

Martin GE, Johnson M, Veile R, Friend LA, Elterman JB, Johannigman JA, Pritts TA, Goodman MD, Makley AT. Effects of early altitude exposure on the open abdomen after laparotomy in trauma. Mil Med. 2019; 184(9-10):e460-7.

Baker JE, Martin GE, Katsaros G, Lewis HV, Wakfield CJ, Josephs SA, Nomellini V, Makley AT, Goodman MD. Variability of fluid administration during exploratory laparotomy for abdominal trauma. Trauma Surg Acute Care Open. 2018 3(1): e000240

Martin GE, Heng H, Makley AT, Pritts TA, Elterman JB, Johannigman JA, Goodman MD. Proximal penetrating extremity injuries – an opportunity to decrease overtriage? J Trauma Acute Care Surg. 2018 85(1):122-127.


Hospital Affiliations

Barnes-Jewish Hospital

Christian Hospital

Missouri Baptist Medical Center

Patients Seen At

Barnes-Jewish Hospital
One Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Christian Hospital
11133 Dunn Road
St. Louis, MO 63136

Missouri Baptist Medical Center
3015 North Ballas Road
St. Louis, MO 63131


To request an appointment with an Acute and Critical Care surgeon, please call 314-362-5298.