Taylor C Brown, MD, MHS

Expertise


Specialty Areas


Endocrine and oncologic surgery including surgery for adrenal, parathyroid, and thyroid diseases.

Common Procedures


  • Adrenal surgery
  • Parathyroid surgery
  • Thyroid surgery
  • Laparoscpic cholecystectomy
  • Hernia surgery  

Common Diagnoses Treated


  • Adrenal nodules and cancer
  • Hyperparathyroidism
  • Parathyroid cancer
  • Thyroid nodules
  • Thyroid cancer
  • Graves’ disease
  • Gallbladder disease
  • Inguinal hernia 
  • Umbilica hernia 
  • Ventral Hernia
Education


Board Certifications


American Board of Surgery

Degrees


Medical School: University of Louisville School of Medicine, Louisville, KY, 2011

Graduate School: MHS, Yale University School of Medicine, New Haven, CT, 2015

Residency


2018 – General Surgery Residency, Yale University School of Medicine, New Haven, CT

Fellowship


2019 – Endocrine Surgery Fellowship, Yale University School of Medicine, New Haven, CT

Professional Memberships


American Association of Endocrine Surgeons (Candidate Member)

Yale Surgical Society

St. Louis Surgical Society

Association of VA Surgeons

Awards and Honors


Alpha Omega Alpha Medical Honor Society

Morgan Williams Award, University of Louisville Department of Surgery

Walter E. Pleban, MD Burn Resident of the Year Award, Bridgeport Hospital

Basic Science Resident Research Award, Yale Department of Surgery

Research


Areas of Research Interest


Molecular causes of thyroid and adrenal cancer

Clonal evolution of thyroid cancer

DNA repair dysregulation in thyroid cancer

Clinical Trials


Tissue and blood acquisition for multi-omic analysis and collection of health information for patients with thyroid and adrenal tumors (Washington University Endocrine Neoplasia Laboratory, WENL)

Publications


Brown TC, Nicolson NG, Man J, Gibson CE, Stenman A, Juhlin CC, Korah R, Carling T. Recurrent Amplificiation of the Osmotic Stress Transcription Factor NFAT5 in Adrenocortical Carcinoma. Journal of the Endocrine Society 2020 May 25;4(7). PMID 32587934.

Riccardi A, Lemos C, Ramos R, Bellizzi J, Parham K, Brown TC, Korah R, Carling T, Costa-Guda J, Arnold A. PIK3CA Mutational Analysis of Parathyroid Adenomas. JBMR Plus. 2020 Apr 13;4(6). PMID 32537547.

Nicolson NG, Brown TC, Korah R, Carling T. Immune Cell Infiltrate-Associated Dysregulation of DNA Repair Machinery May Predispose to Papillary Thyroid Carcinogenesis. Surgery. 2020 Jan;26(1):55-65. PMID: 31439400.

Brown TC, Nicolson NG, Stenman A, Juhlin CC, Gibson CE, Callender GG, Korah R, Carling T. Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinomas. Journal of the American College of Surgeons. May 2019 Sep;229(3):305-315. PMID: 31034883.

Riccardi A, Aspir T, Shen L, Kuo CL, Brown TC, Korah R, Murtha TD, Bellizzi J, Parham K, Carling T, Costa-Guda J, Arnold A. Analysis of Activating GCM2 Sequence Variants in Sporadic Parathyroid Adenomas. The Journal of Clinical Endocrinology and Metabolism. 2019 Jun 104(6):1948-1952. PMID: 30624640.

Brown TC, Murtha TD, Rubinstein JC, Korah R Carling T. SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior. Cell Communication and Signaling. 2018 Jun;16(1):27. PMID: 29884238.

Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T. Comprehensive genetic analysis of follicular thyroid cancer predicts prognosis independent of histology. Journal of Clinical Endocrinology and Metabolism. 2018 Jul;107(7):2640-2650. PMID: 29726952.

Brown TC, Nicolson NG, Cheng J, Korah R, Carling T. Charactertization of cell membrane extensions and studying their roles in cancer cell adhesion dynamics. Journal of Visualized Experiments. 2018 Mar;26(133). PMID: 29630043.

Brown TC, Nicolson NG, Korah R, Carling T. BCL9 upregulation in adrenocortical carcinoma: a novel Wnt/β-Catenin activating event driving adrenocortical malignancy. Journal of the American College of Surgeons. 2018 Jun;226(6):988-995. PMID: 29428231.

Romano R, Ellis S, Yu N, Bellizzi J, Brown TC, Korah R, Carling T, Costa-Gulda J, Arnold A. Mutational analysis of ZFY in sporadic parathyroid adenomas. Journal of the Endocrine Society. 2017 Mar;1(4):313-316. PMID: 29264489.

Cheng JY, Brown TC, Murtha TD, Stenman A, Juhlin CC, Larsson C, Healy JM, Prasad ML, Knoefel WT, Krieg A, Scholl UI, Korah R, Carling T. A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis. BMC Cancer. 2017 Mar;17(1):164. PMID: 28249601.

Murtha TD, Brown TC, Rubinstein JC, Haglund F, Juhlin CC, Larsson C, Korah R, Carling T. Overexpression of cytochrome P4502A6 in adrenocortical carcinoma. Surgery. 2017 Jun;161(6):1667-1674. PMID: 28073588.

Rubinstein JC, Brown TC, Christison-Lagay ER, Zhang Y, Kunstman JW, Juhlin CC, Nelson-Williams C, Goh G, Quinn CE, Callender GG, Udelsman R, Lifton RP, Korah R, Carling T. Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma. BMC Cancer. 2016 Aug;16:646. PMID: 27538953.

Brown TC, Juhlin CC, Healy JM, Stenman A, Rubinstein JC, Korah R, Carling T. DNA copy amplification and overexpression of SLC12A7 in adrenocortical carcinoma. Surgery. 2016 Jan;159(1):250-257. PMID: 26454676.

Rubinstein JC, Brown TC, Goh G, Juhlin CC, Stenman A, Korah R, Carling T. Chromosome 19 amplification correlates with advanced disease in adrenocortical carcinoma. Surgery. 2016 Jan;159(1):296-301. PMID: 26453132.

Stenman A, Juhlin CC, Haglund F, Brown TC, Clark VE, Svahn F, Bilguvar K, Goh G, Korah R, Lifton RP, Carling T. Absence of KMT2D/MLL2 mutations in abdominal paraganglioma. Clinical Endocrinology. 2016 Apr;84(4):632-634. PMID: 26303934.

Scholl UI, Healy JM, Thiel A, Fonseca AL, Brown TC, Kunstman JW, Horne MJ, Dietrich D, Riemer J, Kücükköylü S, Reimer EN, Reis AC, Goh G, Kristiansen G, Mahajan A, Korah R, Lifton RP, Prasad ML, Carling T. Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological, and pathological phenotype. Clinical Endocrinology. 2015 Dec;83(6):779-789. PMID: 26252618.

Juhlin CC, Stenman A, Haglund F, Clark VE, Brown TC, Baranoski J, Bilguvar K, Goh G, Welander J, Svahn F, Rubinstein JC, Caramuta S, Yasuno K, Günel M, Bäckdahl M, Gimm O, Söderkvist P, Prasad ML, Korah R, Lifton RP, Carling T. Whole-exome sequencing defines the mutational landscape of pheochromocytoma and identifies KMT2D as a recurrently mutated gene. Genes, Chromosomes & Cancer. 2015 Sep;54(9):542-554. PMID: 26032282.

Haglund F, Juhlin CC, Brown TC, Ghaderi M, Liu T, Stenman A, Dinets A, Prasad M, Korah R, Xu D, Carling T, Larsson C. TERT promoter mutations are rare in parathyroid tumors. Endocrine-Related Cancer. 2015 Jun;22(3):L9-L11. PMID: 25876648.

Kunstman JW, Juhlin CC, Goh G, Brown TC, Stenman A, Healy JM, Rubinstein JC, Choi M, Kiss N, Nelson-Williams C, Mane S, Rimm DL, Prasad ML, Höög A, Zedenius J, Larsson C, Korah R, Lifton RP, Carling T. Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing. Human Molecular Genetics. 2015 Apr;24(8):2318-2329. PMID: 25576899.

Brown TC, Healy JM, McDonald MJ, Hansson JH, Quinn CE. Heart block and acute kidney injury due to hyperparathyroidism-induced hypercalcemic crisis. The Yale Journal of Biology and Medicine. 2014 Dec;87(4):563-567. PMID: 25506288.

Juhlin CC, Goh G, Healy JM, Fonseca AL, Scholl UI, Stenman A, Kunstman JW, Brown TC, Overton JD, Mane SM, Nelson-Williams C, Bäckdahl M, Suttorp AC, Haase M, Choi M, Schlessinger J, Rimm DL, Höög A, Prasad ML, Korah R, Larsson C, Lifton RP, Carling T. Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma. The Journal of Clinical Endocrinology and Metabolism. 2015 Mar;100(3):E493-E502. PMID: 25490274.

Quinn CE, Healy JM, Lebastchi AH, Brown TC, Stein JE, Prasad ML, Callender GG, Carling T, Udelsman R. Modern experience with aggressive parathyroid tumors in a high-volume New England referral center. Journal of the American College of Surgeons. 2015 Jun;220(6):1054-1062. PMID: 25488353.

Brown TC, Juhlin CC, Healy JM, Prasad ML, Korah R, Carling T. Frequent silencing of RASSF1A via promoter methylation in follicular thyroid hyperplasia: a potential early epigenetic susceptibility event in thyroid carcinogenesis. JAMA Surgery. 2014 Nov;149(11):1146-1152. PMID: 25229773.

Liu T, Brown TC, Juhlin CC, Andreasson A, Wang N, Bäckdahl M, Healy JM, Prasad ML, Korah R, Carling T, Xu D, Larsson C. The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors. Endocrine-Related Cancer. 2014 May;21(3):427-434. PMID: 24803525.

Locations


Hospital Affiliations


Barnes-Jewish Hospital

Barnes-Jewish West County Hospital

VA Medical Center – St. Louis

Patients Seen At


Center for Advanced Medicine
Breast Health Center
4921 Parkview Place
Suite F, Floor 5
St. Louis, MO 63110

Barnes-Jewish West County Hospital
Medical Building 4
1044 North Mason Road
Suite 310
St. Louis, MO  63141

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