William C.  Chapman Jr, MD, MPHS

William C. Chapman Jr, MD, MPHS

Assistant Professor of Surgery


Specialty Areas

  • Colon and rectal surgery

Common Diagnoses Treated

  • Anal cancer
  • Carcinomatosis
  • Colon cancer
  • Colon polyps
  • Rectal cancer
  • Constipation
  • Crohn’s disease
  • Diverticulitis
  • Fecal incontinence
  • Fissures
  • Hemorrhoids
  • Peritoneal surface disease
  • Pelvic floor disorders
  • Pilonidal cysts
  • Rectal prolapse
  • Ulcerative colitis

Board Certifications



Bachelor of Arts, University of North Carolina, Chapel Hill, NC, 2009

Medical School: Georgetown University School of Medicine, Washington, D.C., 2015

Master of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, 2018


General Surgery Residency, Washington University School of Medicine, St. Louis, MO, 2002

Walter F. Ballinger Administrative Chief Resident, Washington University School of Medicine, St. Louis, MO, 2021-2022


Colorectal Surgery Fellowship, Cleveland Clinic Foundation, Cleveland, OH, 2022-2023

Professional Memberships

Candidate Member, American College of Surgeons

Member, American Society of Colon and Rectal Surgeons

Reviewer, Diseases of Colon and Rectum

Reviewer, Surgery

Awards and Honors

2018, Wells Resident Research Award, Washington University School of Medicine
2016, Resident Research Presentation Award, Vascular Access Society of America
2015, Alpha Omega Alpha, Georgetown University School of Medicine
2015, Gold Humanism Honor Society, Georgetown University School of Medicine
2008, Phi Beta Kappa, University of North Carolina
2002, Eagle Scout, Boy Scouts of America


Areas of Research Interest

Rectal cancer

Colon cancer

Patient reported outcomes in colorectal surgery


Peer Reviewed

  1. Kuo E, Bharat A, Goers T, Chapman W, Yan L, Street T, Lu W, Walter M, Patterson A, Mohanakumar T. Respiratory viral infection in obliterative airway disease after orthotopic tracheal transplantation. Ann Thorac Surg. 2006 Sep;82(3):1043-50. PMID: 16928532.
  2. Chapman WC Jr, Sosin M, Salameh JR, Espinel CF. The hepatic buttress: A novel surgical technique to treat an intrapericardial diaphragmatic defect after hybrid myocardial ablation. J Thorac Cardiovasc Surg. 2015 Jul;150(1):e5-7. PMID: 25957456.
  3. Chapman WC Jr, Choi P, Hawkins AT, Hunt SR, Silviera ML, Wise PE, Mutch MG,
    Glasgow SC. Benchmarking rectal cancer care: institutional compliance with a
    longitudinal checklist. J Surg Res. 2018 May;225:142-147. PMCID: PMC5881924.
  4. Chapman WC Jr, Nandy S, Rais R, González I, Chatterjee D, Mutch M, Zhu Q. Label free quantitative optical assessment of human colon tissue using spatial frequency domain imaging. Tech Coloproctol. 2018 Aug;22(8):617-621. PMCID: PMC6162989.
  5. Leng X, Chapman W Jr, Rao B, Nandy S, Chen R, Rais R, Gonzalez I, Zhou Q,
    Chatterjee D, Mutch M, Zhu Q. Feasibility of co-registered ultrasound and acoustic resolution photoacoustic imaging of human colorectal cancer. Biomed Opt Express. 2018 Oct 3;9(11):5159-5172. PMCID: PMC6238928.
  6. Rosen DR, Wolfe RC, Damle A, Atallah C, Chapman WC Jr, Vetter JM, Mutch MG, Hunt, SR, Glasgow SC, Wise PE, Smith RK, Silviera ML. Thoracic Epidural Analgesia: Does It Enhance Recovery? Dis Colon Rectum. 2018 Dec;61(12):1403-1409. PMCID: PMC6219916.
  7. Chapman WC Jr, Subramanian M, Jayarajan S, Makhdoom B, Mutch MG, Hunt S, Silviera ML, Glasgow S, Olsen MA, Wise PE. First, Do No Harm: Rethinking Routine Diversion in Sphincter-Preserving Rectal Cancer Resection. J Am Coll Surg. 2019 Jan 9. PMCID: PMC6424605.
  8. Zeng Y, Rao B, Chapman WC Jr, Nandy S, Rais R, González I, Chatterjee D, Mutch M, Zhu Q. The Angular Spectrum of the Scattering Coefficient Map Reveals Subsurface Colorectal Cancer. Sci Rep. 2019 Feb 28;9(1):2998. PMCID: PMC6395629.
  9. Yang G, Amidi E, Chapman W, Nandy S, Mostafa A, Abdelal H, Alipour Z, Chatterjee D, Mutch M, Zhu Q. Co-registered photoacoustic and ultrasound imaging of human colorectal cancer. J Biomed Opt. 2019 Nov;24(12):1-13. PMCID: PMC6238928
  10. Chapman WC Jr, Luo X, Doyle M, Khan A, Chapman WC, Kangrga I, Martin J Jr, Wellen J. Time Is Money: Can Punctuality Decrease Operating Room Cost?. J Am Coll Surg. 2020 Feb;230(2):182-189.e4. PMID: 31843690
  11. González I, Bauer PS, Chapman WC Jr, Alipour Z, Rais R, Liu J, Chatterjee D.
    Clinicopathologic determinants of pathologic treatment response in neoadjuvant treated rectal adenocarcinoma. Ann Diagn Pathol. 2020 Apr;45:151452. PMCID: PMC7195850
  12. Li S, Zeng Y, Chapman WC Jr, Erfanzadeh M, Nandy S, Mutch M, Zhu Q. Adaptive Boosting (AdaBoost)-based multiwavelength spatial frequency domain imaging and characterization for ex vivo human colorectal tissue assessment. J Biophotonics. 2020 Jun;13(6):e201960241. PMCID: PMC7593835
  13. Chen H, Zheng X, Zong X, Li Z, Li N, Hur J, Fritz CD, Chapman WC Jr, Nickel KB,
    Tipping A, Colditz GA, Giovannucci EL, Olsen MA, Fields RC, Cao Y. Metabolic
    syndrome, metabolic comorbid conditions and risk of early-onset colorectal cancer. Gut. 2020 Oct 9. PMID: 33037055.
  14. Zeng Y, Chapman WC Jr, Lin Y, Li S, Mutch M, Zhu Q. Diagnosing colorectal
    abnormalities using scattering coefficient maps acquired from optical coherence tomography. J Biophotonics. 2021 Jan;14(1). PMCID: PMC8196414
  15. Otegbeye EE, Chapman WC Jr, Bauer PS, Smith RK, Glasgow SC, Wise PE, Hunt SR, Silviera ML, Mutch MG. Preoperative Patient-Reported Outcomes Measurement Information System (PROMIS)-Physical Function and Perioperative Complication in Major Abdominal Colorectal Operations. J Am Coll Surg. 2021 Apr;232(4):451-459. PMID: 33383215
  16. Leng, X; Uddin, K; Chapman, WC JR; Luo, H; Kou, S; Amidi, E; Yang, G; Chatterjee, D; Shetty, A; Hunt, S; Mutch, M; Zhu, Q. Assessing rectal cancer treatment response using co-registered endorectal photoacoustic and ultrasound imaging paired with deep learning. Radiology. 2021 May; 299(2):349-358. PMCID: PMC8108559
  17. Leng X, Amidi E, Kou S, Cheema H, Otegbeye E, Chapman WC Jr, Mutch M, Zhu Q. Rectal Cancer Treatment Management: Deep-Learning Neural Network Based on Photoacoustic Microscopy Image Outperforms Histogram-Feature-Based Classification. Front Oncol. 2021 Sept; 11. PMCID: PMC8495416.
  18. Abelson JS, Barron J, Bauer PS, Chapman WC Jr, Schad C, Ohman K, Glasgow S, Hunt S, Mutch M, Smith RK, Wise PE, Silviera M. Travel Time to a High Volume Center Negatively Impacts Timing of Care in Rectal Cancer. J Surg Res. 2021 Oct;266:96-103. PMID: 33989893
  19. Weiser MR, Chou JF, Keshinro A, Chapman WC Jr, Bauer PS, Mutch MG, Parikh PJ, Cercek A, Saltz LB, Gollub MJ, Romesser PB, Crane CH, Shia J, Markowitz AJ, Garcia- Aguilar J, Gönen M; Colorectal Cancer Disease Management Team of Memorial Sloan Kettering Cancer Center. Development and Assessment of a Clinical Calculator for Estimating the Likelihood of Recurrence and Survival Among Patients With Locally Advanced Rectal Cancer Treated With Chemotherapy, Radiotherapy, and Surgery. JAMA Netw Open. 2021 Nov 1;4(11):e2133457. PMCID: PMC8576585
  20. Chapman WC Jr, Kim H, Bauer P, Makhdoom BA, Trikalinos NA, Pedersen KS,
    Glasgow SC, Mutch MG, Silviera ML, Roy A, Parikh PJ, Hunt SR. Total Neoadjuvant Therapy With Short-Course Radiation: US Experience of a Neoadjuvant Rectal Cancer Therapy. Dis Colon Rectum. 2022 Feb 1;65(2):198-206. PMID: 34990423
  21. Bauer PS, Chapman WC Jr, Atallah C, Makhdoom BA, Damle A, Smith RK, Wise PE, Glasgow SC, Silviera ML, Hunt SR, Mutch MG. Perioperative Complications After Proctectomy for Rectal Cancer: Does Neoadjuvant Regimen Matter? Ann Surg. 2022 Feb 1;275(2):e428-e432. PMCID: PMC8245013
  22. Luo H, Li S, Zeng Y, Cheema H, Otegbeye E, Ahmed S, Chapman WC Jr, Mutch M, Zhou C, Zhu Q. Human Colorectal Cancer Tissue Assessment Using Optical Coherence Tomography Catheter and Deep Learning. J Biophotonics. 2022 Feb 11:e202100349. PMID: 35150067
  23. Chapman WC Jr, Zhu Q. Deep learning based on co-registered ultrasound and
    photoacoustic imaging improves the assessment of rectal cancer treatment response. J Biomed Opt. 2023 April
  24. Zarate JG. Chapman WC Jr, Sanford DE, Hammill CW, Wise PE, Smith RK, Glasgow SC, Silviera ML. Social vulnerability is associated with more stomas after surgery for uncomplicated diverticulitis. Surgery in Practice and Science. Volume 13. 2023
  25. Chapman WC Jr, Henke L, Hunt SR. Radiotherapy for rectal cancer – how much is enough? Clinics in Colon and Rectal Surgery. 2023.

Reviews, Chapters, and Editorials

  1. Chapman WC Jr, Subramanian M, Klingensmith ME, Wellen J. The pillars of personal financial success: Filling a critical gap in surgical education. Bull Am Coll Surg. 2018 Sept 1; 103(9):54.
  2. Chapman WC Jr, Chapman WC. Disorders of the Spleen. In: Greer JP, Arber DA,
    Glader BE, List AF, Means RT, Rodgers GM (eds.). Wintrobe’s Clinical Hematology.
    Fourteenth Edition. Philadelphia: Wolters Kluwer; 1394-1407. 2019.
  3. Chapman WC Jr, Mutch MG. Open Left and Sigmoid Colectomy – Lateral to Medial. In: Wexner SD, Fleshman JW (eds.). Colon and Rectal Surgery: Abdominal Operations. Second Edition. Philadelphia: Wolters Kluwer; 57 – 64. 2019.
  4. Chapman WC Jr, Mutch MG. Anorectal Disease. In: Wise PE, Klingensmith ME, Yu J, Ohman K (eds.). The Washington Manual of Surgery. Eighth Edition. Philadelphia: Wolters Kluwer; 464 – 477. 2020.
  5. Parikh PJ, Chapman WC Jr. Same results, 20% of the cost: Short-course total
    neoadjuvant therapy. Int J Radiat Oncol Biol Phys. 2020 Mar 15;106(4):672-673. PMID: 31924409
  6. Chapman WC Jr, Luo X, Wellen J. Punctuality Matters: Starting on Time Remains Key Among Many Factors: In Reply to Tsai and Dexter. J Am Coll Surg. 2020 May;230(5):839. PMID: 32093968.
  7. Zhang F, Chapman WC Jr, Bochicchio G, Ilahi O, Osborn T. The Importance of
    Universal Preprocedural Testing for the Novel Coronavirus 2019. Crit Care Explor. 2020 May 22;2(5):e0133. PMID: 32671353
  8. Chapman WC Jr, Mutch MG. Total Abdominal Colectomy: Laparoscopic Technique. In: Hawn M, Albo D, Brown K, et al (eds). Operative Techniques in Surgery. Second Edition. Philadelphia: Wolters Kluwer; 2022.


  1. Chapman WC Jr, Roxburgh C, Makhdoom B, Roy A, Youssef FF, Brady P, Olsen JR, Kim H, Pedersen K, Mutch MG, Markovina S, Hajj C, Cercek A, Weiser M, Parikh PJ. Rectal cancer downstaging is significantly improved with different regimens of total neoadjuvant therapy. American Society for Radiation Oncology 60th Annual Meeting. San Antonio, TX. October 23, 2018.
  2. Chapman WC Jr, Subramanian M, Jayarajan S, Makhdoom B, Hunt SR, Silviera ML, Glasgow SC, Olsen M, Mutch MG, Wise PE. First, Do No Harm: Rethinking routine diversion in sphincter-preserving rectal cancer resection. Southern Surgical Association Annual Scientific Meeting. Palm Beach, FL. December 4, 2018.
  3. Chapman WC Jr, Kim H, Bauer P, Makhdoom B, Trikalinos N, Pedersen K, Glasgow WC, Mutch MG, Roy A, Roach M, Parikh PJ, Hunt SR. Total neoadjuvant therapy with short-course radiation compared to chemoradiation in rectal cancer. 2019 Gastrointestinal Cancers Symposium. San Francisco, CA. January 21, 2019.
  4. Luo X, Chapman WC Jr, Doyle M, Khan A, Chapman WC, Kangrga I, Martin J Jr, Wellen J. Time is Money: Can Punctuality Decrease Operating Room Cost? 2019 American College of Surgeons Clinical Congress. San Francisco, CA. October 28, 2019.
  5. Chapman WC Jr. Modern Surgical Education: adapt or die. The Warren H. Cole
    Endowed Lectureship. Sikeston, MO. August 31, 2020.

Hospital Affiliations

Barnes-Jewish Hospital

Patients Seen At

Center for Advanced Medicine
4921 Parkview Place, Suite 8C
GI Center
St. Louis, MO 63110
Telephone: 314-454-7177
Fax: 888-425-7946

Barnes-Jewish West County Hospital
Medical Building 4
1044 North Mason Road
Suite 310
St. Louis, MO  63141
Telephone: 314-454-7177
Fax: 888-425-7946


To request an appointment with Dr. Chapman, please call 314-454-7177.