Obesity is a complex and chronic disease characterized by excess body fat that can lead to a variety of health complications.
It is typically determined using the body mass index (BMI), which evaluates weight relative to height.
Obesity is a significant public health issue that affects a large portion of the global population. Obesity can be a risk factor for numerous other health problems.
Understanding, including its definition, causes, symptoms, diagnosis, health risks, and management strategies, can help people make decisions about their health.
What is obesity?
Obesity is defined as having an excessive amount of body fat, typically measured by BMI.
- Overweight: BMI between 25 and 29.9
- Obesity: BMI of 30 or higher
- Severe obesity: BMI of 40 or higher or 35 with obesity-related health conditions
Causes of obesity
Genetic factors
- Genetics: Genetic predisposition can influence body weight by affecting metabolism, fat storage, and appetite.
Lifestyle factors
- Diet: Consuming a high-calorie diet, especially including foods high in fats and sugars, can contribute to weight gain.
- Physical inactivity: Sedentary lifestyle with little physical activity can lead to weight gain over time.
- Behavioral factors: Emotional eating, lack of sleep, and stress can influence eating habits and weight.
Environmental factors
- Food environment: Easy access to fast food and processed foods can promote unhealthy eating habits.
- Socioeconomic factors: Limited access to healthy food options and recreational facilities can contribute to obesity.
Medical and psychological factors
- Medications: Certain medications, such as steroids and antidepressants, can cause weight gain.
- Medical conditions: Conditions like hypothyroidism, polycystic ovary syndrome (PCOS), and Cushing’s syndrome can contribute to weight gain.
- Mental health: Anxiety, depression, and other psychological issues can lead to overeating and weight gain.
Symptoms of obesity
Physical symptoms
- Excess body fat: Noticeable accumulation of fat, particularly around the waist.
- Difficulty with physical activity: Reduced ability to perform daily tasks and exercise due to excess weight.
- Breathlessness: Experience shortness of breath with physical exertion.
Psychological symptoms
- Low self-esteem: Negative self-image and low confidence due to weight.
- Social isolation: Avoiding social interactions and activities due to weight concerns.
Diagnosis of obesity
Body mass index (BMI)
- BMI calculation: BMI is calculated by dividing weight in kilograms by the square of height in meters. It is the most common method for diagnosing obesity.
Physical examination
- Measurement of waist circumference: Increased waist circumference can indicate higher risk of obesity-related health problems.
- Assessment of health conditions: Evaluation of obesity-related health issues, such as hypertension and diabetes.
Blood tests
- Blood glucose levels: To check for diabetes or insulin resistance.
- Cholesterol levels: To evaluate lipid profiles and risk of cardiovascular diseases.
- Liver function tests: To assess the impact of obesity on liver health.
Health risks associated with obesity
Metabolic health risks
- Type 2 diabetes: Increased risk of insulin resistance and diabetes.
- High blood pressure: Elevated blood pressure leading to cardiovascular issues.
- Heart disease: Higher likelihood of developing heart conditions, including coronary artery disease.
Learn more about cardiac surgery at WashU Medicine>>
Respiratory health risks
- Sleep apnea: Increased risk of obstructive sleep apnea due to excess fat around the neck.
- Asthma: Worsened asthma symptoms and respiratory issues.
Musculoskeletal health risks
- Osteoarthritis: Increased stress on joints, leading to arthritis and joint pain.
- Back pain: Higher incidence of back pain due to excess weight.
Reproductive health risks
- Infertility: Hormonal imbalances affecting fertility in both men and women.
- Pregnancy complications: Greater risk of gestational diabetes, hypertension, and complications during childbirth.
Management of obesity
Lifestyle modifications
- Healthy eating: Adopting a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats while reducing the intake of processed foods, sugary beverages, and high-calorie snacks.
- Regular physical activity: Incorporating regular exercise into daily routines, including aerobic exercises (such as walking, jogging, swimming) and strength training. Aim for at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous activity per week.
- Behavioral therapy: Counseling and support to help identify and address barriers to weight loss, develop healthy eating habits, and manage emotional eating.
Medical interventions
- Prescription medications: In some cases, health care providers may prescribe medications to assist with weight loss. Examples include generic names such as orlistat, liraglutide, and phentermine-topiramate. These medications should be used under medical supervision and in conjunction with lifestyle modifications.
- Weight loss programs: Structured programs that provide guidance, support, and resources for weight management.
Learn more about non-surgical weight loss>>
Surgical interventions
- Bariatric surgery: Procedures such as gastric bypass, sleeve gastrectomy, and duodenal switch that can aid in weight loss by reducing stomach size and altering digestion. Surgery is typically considered for individuals with severe obesity and obesity-related health conditions who have not succeeded with non-surgical methods.
Learn more about bariatric (weight loss) surgery at WashU Medicine>>
Potential risks and complications of obesity management
Non-surgical approach risks
- Nutritional deficiencies: Risk of deficiencies due to restrictive diets can be mitigated by careful planning and supplementation.
- Eating disorders: Risk of developing unhealthy eating behaviors or disordered eating patterns; balanced and sustainable approaches are essential.
Medication-related risks
- Side effects: Weight-loss medications may cause gastrointestinal issues, increased heart rate, or mood changes. Discuss potential side effects with healthcare providers.
- Long-term use: Some weight-loss medications may not be suitable for long-term use and should be monitored by health care providers.
Surgical risks
- Complications from surgery: Risks include infection, bleeding, leaks from staple lines, and nutritional deficiencies. Discuss potential risks and benefits with a healthcare professional.
Obesity is a complex condition requiring a multifaceted approach for effective management.
Combining lifestyle modifications, behavioral strategies, dietary changes, medications, and possibly surgical interventions can help individuals achieve sustained weight loss and improve health outcomes.
If you are struggling with obesity, consult with a health care professional to develop a personalized plan tailored to your specific needs and goals.




