Zachary Smith, MD


Specialty Areas

Urologic Oncology

Common Procedures

  • Radical cystectomy (including ileal conduit, neobladder, Indiana pouch)
  • Nephrectomy (including IVC thrombectomy)
  • Partial nephrectomy
  • Prostatectomy
  • Retroperitoneal lymph node dissection (RPLND)
  • Penectomy
  • Adrenalectomy
  • Transurethral resection of bladder tumor (TURBT)
  • Performing all approaches to surgery including open, robotic, laparoscopic, endoscopic, and percutaneous.

Common Diagnoses Treated

  • Bladder Cancer
  • Kidney Cancer
  • Prostate Cancer
  • Testicular Cancer
  • Penile Cancer
  • Urethral Cancer
  • Adrenal Cancer Sarcoma

Board Certifications



Medical School: University of Missouri, Kansas City, MO, 2010


2015 Urology Residency, University of Pennsylvania, Philadelphia, PA


2018 Urologic Oncology Fellowship, The University of Chicago, Chicago, IL

Professional Memberships

American Urological Association

Society of Urologic Oncology

Société Internationale d’Urologie

American College of Surgeons

Awards and Honors

2020 Charles B. Manley Teaching Award, Washington University School of Medicine, Division of Urology

2019 Charles B. Manley Teaching Award, Washington University School of Medicine, Division of Urology

University of Pennsylvania, Chief Resident

Outstanding Technical Excellence in Urologic Surgery

Société Internationale d’Urologie US National Chapter Travel Scholarship

AUA National Chief Resident Debate winner

Alpha Omega Alpha Honor Medical Society


Areas of Research Interest

Clinical trials

Cancer biomarkers

Bladder cancer

Kidney cancer

Testicular cancer

Penile cancer

Optimization of patients for surgery


Clinical Trials

Financial Disclosures

Consultant for Photocure



Hospital Affiliations

Barnes-Jewish Hospital

Patients Seen At

Center for Advanced Medicine
4921 Parkview Place
11th Floor, Suite C
St. Louis, MO 63110

Center for Advanced Medicine-South County
5201 Midamerica Place
St. Louis, MO 63129

Siteman Cancer Center South St. Louis County
5225 Midamerica Place
St. Louis, MO 63129


To request an appointment with Dr. Smith, please call (314) 362-8200.